Cytotoxic constituents from Plumbago zeylanica

被引：97

作者：

Nguyen, AT

Malonne, H

Duez, R

Vanhaelen-Fastre, R

Vanhaelen, M

Fontaine, J

机构：

[1] Free Univ Brussels, Inst Pharm, Lab Pharmacognosie, B-1050 Brussels, Belgium

[2] Free Univ Brussels, Inst Pharm, Lab Physiol & Pharmacol Fondamentals, B-1050 Brussels, Belgium

来源：

FITOTERAPIA | 2004年 / 75卷 / 05期

关键词：

Plumbago zeylanica; cytotoxicity; beta-sitosteryl-3 beta-glucopyranoside-6 '-O-palmitate; plumbagin;

D O I：

10.1016/j.fitote.2004.03.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The bioassay-guided fractionation of the dichloromethane extract of aerial parts of Plumbago zeylanica led to the isolation of beta-sitosterol, beta-sitosteryl-3beta-glucopyranoside, beta-sitosteryl-3beta-glucopyranoside-6'-O-palmitate (1), lupenone, lupeol acetate, plumbagin and trilinolein. Compound 1 showed cytotoxic activity against MCF7 and Bowes cancer cell lines (IC50 113 muM and 152 muM, respectively), beta-sitosterol inhibited Bowes cell growth (IC50 36.5 muM) and plumbagin was cytotoxic against MCF7 and Bowes cells (IC50 1.28 muM and 1.39 muM, respectively). (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：500 / 504

页数：5

共 17 条

[1] Using simple 13C NMR linewidth and relaxation measurements to make detailed chemical shift assignments in triacylglycerols and related compounds [J].