Antimicrobial Stewardship and Environmental Decontamination for the Control of Clostridium difficile Transmission in Healthcare Settings

被引：10

作者：

Bintz, Jason ^{[1
]}

Lenhart, Suzanne ^{[2
]}

Lanzas, Cristina ^{[3
]}

机构：

[1] Houghton Coll, Dept Math, Houghton, NY 14744 USA

[2] Univ Tennessee, Dept Math, Knoxville, TN 37996 USA

[3] North Carolina State Univ, Dept Populat Hlth & Pathobiol, Raleigh, NC 27607 USA

来源：

BULLETIN OF MATHEMATICAL BIOLOGY | 2017年 / 79卷 / 01期

基金：

美国国家科学基金会;

关键词：

Clostridium difficile; Control; Agent-based model; NOSOCOMIAL TRANSMISSION; ANTIBIOTIC STEWARDSHIP; ASYMPTOMATIC CARRIERS; RISK-FACTORS; INFECTION; MODEL; EPIDEMIOLOGY; IMPACT; STRATEGIES; GUIDELINES;

D O I：

10.1007/s11538-016-0224-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We implement an agent-based model for Clostridium difficile transmission in hospitals that accounts for several processes and individual factors including environmental and antibiotic heterogeneity in order to evaluate the efficacy of various control measures aimed at reducing environmental contamination and mitigating the effects of antibiotic use on transmission. In particular, we account for local contamination levels that contribute to the probability of colonization and we account for both the number and type of antibiotic treatments given to patients. Simulations illustrate the relative efficacy of several strategies for the reduction of nosocomial colonizations and nosocomial diseases.

引用

页码：36 / 62

页数：27

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[2]

[Anonymous], 2013, NAT ACT PLAN PREV HL

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