Facile preparation and functionalization of chiral stabilized ylides from common chiral auxiliaries using triphenylphosphoranylideneketene (the bestmann ylide) and their use in Wittig reactions

被引：11

作者：

Boeckman, Robert K., Jr. ^{[1
]}

Song, Xinyi ^{[1
]}

Pero, Joseph E. ^{[1
]}

机构：

[1] Univ Rochester, Dept Chem, Rochester, NY 14627 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 23期

关键词：

D O I：

10.1021/jo061732y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Camphor-derived lactams and other related chiral controllers have been found to react with the Bestmann ylide (triphenyl-phosphoranylideneketene) upon heating in toluene. The resulting parent ylides provide convenient access to a structurally diverse set of chiral stabilized ylides via functionalization. The utility of these chiral ylides for Wittig reactions has been briefly investigated and the effects of alpha-substitution noted.

引用

页码：8969 / 8972

页数：4

共 45 条

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