Shorter duration of breastfeeding at elevated exposures to perfluoroalkyl substances

被引:44
|
作者
Timmermann, Clara Amalie Gade [1 ]
Budtz-Jorgensen, Esben [2 ]
Petersen, Maria Skaalum [3 ]
Weihe, Pal [3 ,4 ]
Steuerwald, Ulrike [3 ]
Nielsen, Flemming [1 ]
Jensen, Tina Kold [1 ]
Grandjean, Philippe [1 ,5 ]
机构
[1] Univ Southern Denmark, Dept Environm Med, JB Winslows Vej 17A, DK-5000 Odense C, Denmark
[2] Univ Copenhagen, Sect Biostat, Oster Farimagsgade 5, DK-1014 Copenhagen, Denmark
[3] Dept Occupat Med & Publ Hlth, Sigmundargota 5 100, Torshavn, Faroe Islands, Denmark
[4] Univ Faroe Islands, Fac Nat & Hlth Sci, JC Svabos Gota 14 100, Torshavn, Faroe Islands, Denmark
[5] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, 677 Huntington Ave, Boston, MA 02115 USA
关键词
Breast milk; Breastfeeding; Endocrine disruption; Lactation; Maternal health; Perfluoroalkyl substances; MAMMARY-GLAND DEVELOPMENT; PERFLUOROOCTANOIC ACID; SERUM CONCENTRATIONS; PREGNANCY; GROWTH; PREDICTORS; LACTATION; CHILDREN; WOMEN; PFOA;
D O I
10.1016/j.reprotox.2016.07.010
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The aim of this study was to determine whether maternal exposure to persistent perfluoroalkyl substances (PFASs) affect the capability to breastfeed. In two Faroese birth cohorts (N = 1130), concentrations of five PFASs were measured in maternal serum during pregnancy or two weeks after term. Duration of breastfeeding was assessed by questionnaire and clinical interview. In adjusted linear regression models, a doubling of maternal serum PFASs was associated with a reduction in duration of both total and exclusive breastfeeding, most pronounced for perfluorooctane sulfonic acid (PFOS) where a doubling was associated with a reduction in total breastfeeding of 1.4 (95% CI: 0.6; 2.1) months and perfluorooctanoic acid (PFOA) where a doubling was associated with a reduction in exclusive breastfeeding of 0.5 (0.3; 0.7) months. The associations were evident among both primiparous and multiparous women, and thus cannot be explained by confounding from previous breastfeeding. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:164 / 170
页数:7
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