A short synthesis of (1S,2R) and (1R,2R)-[1-H-2]-glycerols

被引：5
作者：
Nieschalk, J [1 ]
OHagan, D [1 ]
机构：
[1] UNIV DURHAM,DEPT CHEM,SCI LABS,DURHAM DH1 3LE,ENGLAND
来源：
TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 14期
关键词：
D O I：
10.1016/S0957-4166(97)00219-X
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A straightforward three step route to (1S,2R)- and (1R,2R)-[H-2]-glycerols 1a and 1b is reported. The key asymmetric step involves an AD-mix-beta dihydroxylation on deuterium labelled Z- and E-allyl benzoates 4a and 4b. The route should facilitate the use of [H-2]-glycerols 1a-1d in high enantiomeric purity (95%ee) in biosynthesis investigations. (C) 1997 Elsevier Science Ltd.
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页码：2325 / 2330
页数：6
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