A short synthesis of (1S,2R) and (1R,2R)-[1-H-2]-glycerols

被引：5

作者：

Nieschalk, J ^{[1
]}

OHagan, D ^{[1
]}

机构：

[1] UNIV DURHAM,DEPT CHEM,SCI LABS,DURHAM DH1 3LE,ENGLAND

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 14期

关键词：

D O I：

10.1016/S0957-4166(97)00219-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A straightforward three step route to (1S,2R)- and (1R,2R)-[H-2]-glycerols 1a and 1b is reported. The key asymmetric step involves an AD-mix-beta dihydroxylation on deuterium labelled Z- and E-allyl benzoates 4a and 4b. The route should facilitate the use of [H-2]-glycerols 1a-1d in high enantiomeric purity (95%ee) in biosynthesis investigations. (C) 1997 Elsevier Science Ltd.

引用

页码：2325 / 2330

页数：6

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