Genetic association analysis of 5-HT6 receptor gene polymorphism (267C/T) with tardive dyskinesia

被引:23
作者
Ohmori, O [1 ]
Shinkai, T [1 ]
Hori, H [1 ]
Nakamura, J [1 ]
机构
[1] Univ Occupat & Environm Hlth, Dept Psychiat, Sch Med, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan
关键词
schizophrenia; tardive dyskinesia; 5-HT6; receptor; polymorphism; genetic association;
D O I
10.1016/S0165-1781(02)00095-1
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Possible involvement of serotonergic (5-hydroxytryptamine: 5-HT) receptors in the pathophysiology of tardive dyskinesia (TD) has been suggested. In the present study. the relationship between the 5-HT, receptor gene (HTR6) polymorphisms and TD was studied in 173 Japanese patients with schizophrenia. The 267C/T allele of HTR6 was genotyped using PCR amplification followed by endonuclease digestion. The patients with the three 267C/T genotypes showed no significant difference in gender, age, duration of illness, or cur-rent antipsychotic dose. In addition, there were no significant differences in total AIMS scores among patients with the three genotypes. Moreover, no significant differences in genotypes and allele frequencies were observed between subjects with and without TD. These results suggest that the 267C/T polymorphism of HTR6 does not confer increased susceptibility to TD. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:97 / 102
页数:6
相关论文
共 31 条
[11]  
Kohen R, 1996, J NEUROCHEM, V66, P47
[12]   Lack of association between the T→C 267 serotonin 5-MT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia [J].
Masellis, M ;
Basile, VS ;
Meltzer, HY ;
Lieberman, JA ;
Sevy, S ;
Goldman, DA ;
Hamblin, MW ;
Macciardi, FM ;
Kennedy, JL .
SCHIZOPHRENIA RESEARCH, 2001, 47 (01) :49-58
[13]  
MELTZER HY, 1994, J CLIN PSYCHIAT, V55, P47
[14]   The role of serotonin in antipsychotic drug action [J].
Meltzer, HY .
NEUROPSYCHOPHARMACOLOGY, 1999, 21 (02) :S106-S115
[15]  
MONSMA FJ, 1993, MOL PHARMACOL, V43, P320
[16]   Tardive dyskinesia and debrisoquine 4-hydroxylase (CYP2D6) genotype in Japanese schizophrenics [J].
Ohmori, O ;
Suzuki, T ;
Kojima, H ;
Shinkai, T ;
Terao, T ;
Mita, T ;
Abe, K .
SCHIZOPHRENIA RESEARCH, 1998, 32 (02) :107-113
[17]  
ROTH BL, 1994, J PHARMACOL EXP THER, V268, P1403
[18]  
SCHOOLER NR, 1982, ARCH GEN PSYCHIAT, V39, P486
[19]   Association between the serotonin 2C receptor gene and tardive dyskinesia in chronic schizophrenia:: additive contribution of 5-HT2Cser and DRD3gly alleles to susceptibility [J].
Segman, RH ;
Heresco-Levy, U ;
Finkel, B ;
Inbar, R ;
Neeman, T ;
Schlafman, M ;
Dorevitch, A ;
Yakir, A ;
Lerner, A ;
Goltser, T ;
Shelevoy, A ;
Lerer, B .
PSYCHOPHARMACOLOGY, 2000, 152 (04) :408-413
[20]   Association between the serotonin 2A receptor gene and tardive dyskinesia in chronic schizophrenia [J].
Segman, RH ;
Heresco-Levy, U ;
Finkel, B ;
Goltser, T ;
Shalem, R ;
Schlafman, M ;
Dorevitch, A ;
Yakir, A ;
Greenberg, D ;
Lerner, A ;
Lerer, B .
MOLECULAR PSYCHIATRY, 2001, 6 (02) :225-229