Lower plasma vitamin e levels are associated with the frailty syndrome: The InCHIANTI study

被引:134
作者
Ble, A
Cherubini, A
Volpato, S
Bartali, B
Walston, LD
Windham, BG
Bandinelli, S
Lauretani, F
Guralnik, JM
Ferrucci, L
机构
[1] Harbor Hosp, NIA, Longitudinal Studies Sect, Clin Res Branch,Natl Inst Hlth, Baltimore, MD 21225 USA
[2] Univ Perugia, Inst Gerontol & Geriatr, I-06100 Perugia, Italy
[3] Univ Ferrara, Sect Internal Med & Geriatr, Dept Clin & Expt Med, I-44100 Ferrara, Italy
[4] Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
[5] Johns Hopkins Univ, Div Geriatr Med & Gerontol, Baltimore, MD USA
[6] Azienda Sanit Firenze, Geriatr Rehabil Unit, Florence, Italy
[7] Tuscany Reg Hlth Agcy, Florence, Italy
[8] NIA, Lab Epidemiol Demog & Biometry, NIH, Bethesda, MD 20892 USA
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2006年 / 61卷 / 03期
关键词
D O I
10.1093/gerona/61.3.278
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background. The primary biologic mechanism that causes frailty in older persons has never been adequately explained. According to recent views, oxidative stress may be the driving force of this condition. We tested the hypothesis that, independent of confounders, low plasma levels of vitamin E (alpha-locopherol), the main fat-soluble human antioxidant, are associated with the frailty syndrome in older persons free from dementia and disability. Methods. The study sample included 827 older (>= 65 years) persons (women, 54%) who participated in a population based epidemiological study. Frail participants were identified based on the presence of at least three of live of the following features: self-reported weight loss, low energy, slow gait speed, low grip strength, and low physical activity. Participants with none of these features were considered nonfrail, while participants with one or two were considered intermediate frail. Plasma vitamin E levels were determined using reverse-phase high-performance liquid chromatography. Measured confounders included lower extremity muscle strength, cognitive function, diseases, and factors related to vitamin E metabolism. Results. Age- and gender-adjusted levels of vitamin E decreased gradually from the nonfrail to the frail group (p for trend=.015). In the logistic model adjusted for multiple potential confounders, participants in the highest vitamin E tertile were less likely to be frail than were participants in the lowest vitamin E tertile (odds ratio, 0.30; 95% confidence interval, 0.10-0.91). Conclusions. Our findings show an association between low circulating levels of one of the most important components of the human antioxidant system and the presence of frailty.
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页码:278 / 283
页数:6
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