Combined thalamic and subthalamic deep brain stimulation for tremor-dominant Parkinson's disease

被引:17
|
作者
Oertel, Markus F. [1 ]
Schupbach, W. Michael M. [2 ]
Ghika, Joseph-Andre [3 ]
Stieglitz, Lennart H. [1 ,4 ]
Fiechter, Michael [1 ]
Kaelin-Lang, Alain [2 ,5 ]
Raabe, Andreas [1 ]
Pollo, Claudio [1 ]
机构
[1] Univ Bern, Dept Neurosurg, Inselspital, Univ Hosp Bern, Freiburgstr 10, CH-3010 Bern, Switzerland
[2] Univ Bern, Dept Neurol, Inselspital, Univ Hosp Bern, Bern, Switzerland
[3] Hop Valais, Dept Neurol, Sion, Switzerland
[4] Univ Zurich, Univ Zurich Hosp, Dept Neurosurg, Zurich, Switzerland
[5] Neuroctr Southern Switzerland, Lugano, Switzerland
关键词
Deep brain stimulation; Parkinson's disease; Subthalamic nucleus; Thalamic ventral intermediate nucleus; Tremor; CENTROMEDIAN-PARAFASCICULARIS COMPLEX; GLOBUS-PALLIDUS INTERNUS; BILATERAL IMPLANTATION; VENTRALIS INTERMEDIUS; NUCLEUS STIMULATION; PEDUNCULOPONTINE; OUTCOMES; SURGERY;
D O I
10.1007/s00701-016-3044-5
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Deep brain stimulation (DBS) in the thalamic ventral intermediate (Vim) or the subthalamic nucleus (STN) reportedly improves medication-refractory Parkinson's disease (PD) tremor. However, little is known about the potential synergic effects of combined Vim and STN DBS. We describe a 79-year-old man with medication-refractory tremor-dominant PD. Bilateral Vim DBS electrode implantation produced insufficient improvement. Therefore, the patient underwent additional unilateral left-sided STN DBS. Whereas Vim or STN stimulation alone led to partial improvement, persisting tremor resolution occurred after simultaneous stimulation. The combination of both targets may have a synergic effect and is an alternative option in suitable cases.
引用
收藏
页码:265 / 269
页数:5
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