A "turn-on" fluorescent and colorimetric sensor for selective detection of Cu2+ in aqueous media and living cells

被引：56

作者：

An, Ruibing ^{[1
]}

Zhang, Datong ^{[1
]}

Chen, Yan ^{[2
]}

Cui, Yue-zhi ^{[1
]}

机构：

[1] Qilu Univ Technol, Sch Chem & Pharmaceut Engn, Shandong Prov Key Lab Fine Chem, Jinan 250353, Shandong, Peoples R China

[2] Shandong Blood Ctr, Jinan 250014, Shandong, Peoples R China

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2016年 / 222卷

基金：

中国国家自然科学基金;

关键词：

Dicyanoisophorone; Picolinate; Copper ion; Hydrolysis reaction; Chemodosimeter; Fluorescence enhancement; COPPER; PROBE; CHEMODOSIMETER; CHEMOSENSOR; ALZHEIMERS; METALS; PRION; ION;

D O I：

10.1016/j.snb.2015.08.035

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A dicyanoisophorone-based turn-on chemodosimeter 1 has been designed and synthesized to detect Cu2+ in aqueous media via selective hydrolysis reaction of the picolinate moiety accompanied with generating the fluorophore. The probe 1 exhibited remarkably selective fluorescence enhancement with a 164 nm Stokes shift and highly significant color change to Cu2+ over other metal ions. The limit of detection of probe 1 was calculated as low as 0.2 mu M for Cu2+. The probe 1 was also successfully applied to fluorescence imaging of Cu2+ in HeLa cells. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：48 / 54

页数：7

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