The signaling of chemokine stromal cell-derived factor (SDF)-1 and its receptor C-X-C motif chemokine receptor 4 (CXCR4) is involved in the cellular proliferation, survival, and migration of various cell types. Although SDF-1/CXCR4 has been implicated in the maintenance of the spermatogonial population during mouse testis development, their expression patterns and functions in boar testis remain unclear. In the present study, the expression pattern of SDF-1 and CXCR4 was determined during pre-pubertal and postpubertal stage boar testes and in vitro cultured porcine spermatogonial stem cells (pSSCs). The role of these proteins in colony formation in cultured pSSCs was also investigated. Interestingly, SDF-1 expression was observed in PGP 9.5-positve spermatogonia in all developing stages of boar testis; however, CXCR4 expression was only detected in spermatogonia from 5-day-old boar testis. In addition, SDF-1 and CXCR4 expression was observed in cultured pSSCs from 5-day-old boar testes, and inhibition of the CXCR4 receptor signaling pathway by AMD3100 significantly decreased the colony formation of pSSCs. These results suggest that SDF-1 and CXCR4 are useful markers for detecting stage-specific spermatogonia in boar testis. Our results reveal the role of the SDF-1/CXCR4 axis in pSSC in vitro culture. (C) 2018 Elsevier Inc. All rights reserved.
机构:
Univ Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Grisanti, Laura
;
Falciatori, Ilaria
论文数: 0引用数: 0
h-index: 0
机构:
Weill Cornell Med Coll New York, Howard Hughes Med Inst, Dept Med Genet, New York, NY USAUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Falciatori, Ilaria
;
Grasso, Margherita
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Grasso, Margherita
;
Dovere, Lisa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Dovere, Lisa
;
Fera, Stefania
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Fera, Stefania
;
Muciaccia, Barbara
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Muciaccia, Barbara
;
Fuso, Andrea
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Surg, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Fuso, Andrea
;
Berno, Valeria
论文数: 0引用数: 0
h-index: 0
机构:
EMBL Monterotondo Rome, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Berno, Valeria
;
Boitani, Carla
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Boitani, Carla
;
Stefanini, Mario
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Stefanini, Mario
;
Vicini, Elena
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
机构:
Univ Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Grisanti, Laura
;
Falciatori, Ilaria
论文数: 0引用数: 0
h-index: 0
机构:
Weill Cornell Med Coll New York, Howard Hughes Med Inst, Dept Med Genet, New York, NY USAUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Falciatori, Ilaria
;
Grasso, Margherita
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Grasso, Margherita
;
Dovere, Lisa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Dovere, Lisa
;
Fera, Stefania
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Fera, Stefania
;
Muciaccia, Barbara
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Muciaccia, Barbara
;
Fuso, Andrea
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Surg, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Fuso, Andrea
;
Berno, Valeria
论文数: 0引用数: 0
h-index: 0
机构:
EMBL Monterotondo Rome, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Berno, Valeria
;
Boitani, Carla
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Boitani, Carla
;
Stefanini, Mario
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy
Stefanini, Mario
;
Vicini, Elena
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, ItalyUniv Roma La Sapienza, Fdn Pasteur Cenci Bolognetti, Dept Histol & Med Embryol, Rome, Italy