Comparison of the molecular profile of brain metastases from colorectal cancer and corresponding primary tumors

被引：12

作者：

Aprile, Giuseppe ^{[1
]}

Casagrande, Mariaelena ^{[1
]}

De Maglio, Giovanna ^{[2
]}

Fontanella, Caterina ^{[1
]}

Rihawi, Karim ^{[1
]}

Bonotto, Marta ^{[1
]}

Pisa, Federica E. ^{[3
]}

Tuniz, Francesco ^{[4
]}

Pizzolitto, Stefano ^{[2
]}

Fasola, Gianpiero ^{[1
]}

机构：

[1] Univ & Gen Hosp, Dept Oncol, Piazzale S Maria della Misericordia 15, I-33100 Udine, Italy

[2] Univ & Gen Hosp, Dept Pathol, Piazzale S Maria della Misericordia 15, I-33100 Udine, Italy

[3] Univ & Gen Hosp, Inst Hyg & Clin Epidemiol, Piazzale S Maria della Misericordia 15, I-33100 Udine, Italy

[4] Univ & Gen Hosp, Dept Neurosurg, Piazzale S Maria della Misericordia 15, I-33100 Udine, Italy

来源：

FUTURE ONCOLOGY | 2017年 / 13卷 / 02期

关键词：

BRAF; brain metastases; colorectal cancer; KRAS; PIK3CA; RAS; HEPATIC RESECTION; MUTATIONS; KRAS; CARCINOMA; SURVIVAL; MODEL;

D O I：

10.2217/fon-2016-0196

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: Little is known about molecular biology of brain metastasis (BM) from colorectal cancer and its concordance with matched primary tumors. Materials & methods: We identified 56 consecutive colorectal cancer patients who underwent neurosurgical resection of BM. Tumor samples were tested for KRAS, NRAS, BRAF and PIK3CA. The molecular profile of the brain lesion was compared with the corresponding primary tumor. Results: The molecular profile concordance rate was 95.1%. Median survival after neurosurgery was 5.5 months (95% CI: 4.7-6.3); median overall survival was 24.0 months (95% CI: 15.6-32.4). Conclusion: In this cohort, we report a high frequency of KRAS mutations and a very high concordance rate between the molecular status of BM and that of matched primary tumors.

引用

页码：135 / 144

页数：10

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