Change in electrodermal activity after acute tryptophan depletion associated with aggression in young people with attention deficit hyperactivity disorder (ADHD)

被引：17

作者：

von Polier, G. G. ^{[1
,2
]}

Biskup, C. S. ^{[1
,3
]}

Koetting, W. F. ^{[1
,3
]}

Bubenzer, S. ^{[1
,3
]}

Helmbold, K. ^{[1
,3
]}

Eisert, A. ^{[4
]}

Gaber, T. J. ^{[1
,3
]}

Zepf, F. D. ^{[1
,3
,5
]}

机构：

[1] Rhein Westfal TH Aachen, Clin Child & Adolescent Psychiat Psychosomat & Ps, D-52074 Aachen, Germany

[2] Rhein Westfal TH Aachen, Child Neuropsychol Sect, Clin Child & Adolescent Psychiat Psychosomat & Ps, D-52074 Aachen, Germany

[3] JARA Translat Brain Med, Julich, Germany

[4] Rhein Westfal TH Aachen, Dept Pharm, D-52074 Aachen, Germany

[5] Julich Res Ctr, Inst Neurosci & Med, Julich, Germany

来源：

JOURNAL OF NEURAL TRANSMISSION | 2014年 / 121卷 / 04期

关键词：

Serotonin; ADHD; Electrodermal activity; Physiological arousal; Aggression; AMINO-ACID MIXTURES; PLASMA TRYPTOPHAN; IMPULSIVITY; SEROTONIN; DECREASE; BEHAVIOR; CHILDREN; ANGER; BOYS;

D O I：

10.1007/s00702-013-1119-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated the impact of acute tryptophan depletion (ATD) and reduced brain serotonin synthesis on physiological arousal in 15 young people with ADHD participating in an aggression-inducing game. ATD was not associated with altered physiological arousal, as indexed by electrodermal activity (EDA). Baseline aggression was negatively correlated with the mean ATD effect on EDA. In accordance with the low arousal theory related to aggressive behavior, subjects with reduced physiological responsiveness/lower electrodermal reactivity to ATD tended to display elevated externalizing behavior.

引用

页码：451 / 455

页数：5

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