A new multicomponent synthesis of 1,2,3,4-tetrahydroquinolines

被引：45

作者：

Annunziata, R ^{[1
]}

Cinquini, M ^{[1
]}

Cozzi, F ^{[1
]}

Molteni, V ^{[1
]}

Schupp, O ^{[1
]}

机构：

[1] UNIV MILAN,DIPARTIMENTO CHIM ORGAN & IND,I-20133 MILAN,ITALY

来源：

TETRAHEDRON | 1997年 / 53卷 / 28期

关键词：

D O I：

10.1016/S0040-4020(97)00594-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a variety of differently substituted 1,2,3,4-tetrahydroquinolines by a new three-component reaction involving an imine (Ar-N=CHR), an a-branched and enolizable aldehyde ((RRCHCHO)-R-1-C-2), and a nucleophile (ROH, ArSH, ArNH2, H2O) is described. The in situ generation of the imine (that allows a four-component process), and the reactions of an enantiomerically pure imine and/or aldehyde were also studied. A short discussion of the reaction mechanism is reported. (C) 1997 Elsevier Science Ltd.

引用

页码：9715 / 9726

页数：12

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