Down-regulation of P-glycoprotein expression in MDR breast cancer cell MCF-7/ADR by honokiol

被引：96

作者：

Xu, Dong ^{[1
]}

Lu, Qinghua ^{[1
]}

Hu, Xun ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Affliated Hosp 2, Inst Canc, Hangzhou 310009, Zhejiang Prov, Peoples R China

来源：

CANCER LETTERS | 2006年 / 243卷 / 02期

关键词：

honokiol; P-glycoprotein; drug resistance;

D O I：

10.1016/j.canlet.2005.11.031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

P-glycoprotein accounts for the most intrinsic and acquired cancer multidrug resistance. To inhibit the expression of P-glycoprotein is one of the effective ways to reverse cancer drug resistance. Honokiol, a naturally occurring compound, has been demonstrated to combat cancer through mechanisms including inhibition of angiogenesis and induction of apoptosis. Here, we show that honokiol down-regulated the expression of P-glycoprotein at mRNA and protein levels in MCF-7/ADR, a human breast MDR cancer cell line. The down-regulation of P-glycoprotein was accompanied with a partial recovery of the intracellular drug accumulation, and of the sensitivities toward adriamycin. This study reveals a novel function of honokiol as an anti-cancer agent. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：274 / 280

页数：7

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