Impact of adult growth hormone deficiency on metabolic profile and cardiovascular risk

被引：42
作者：
Giovannini, Lara [1 ]
Tirabassi, Giacomo [1 ]
Muscogiuri, Giovanna [2 ]
Di Somma, Carolina [3 ]
Colao, Annamaria [2 ]
Balercia, Giancarlo [1 ]
机构：
[1] Polytech Univ Marche, Div Endocrinol, Dept Clin & Mol Sci, Umberto Hosp 1,Sch Med, I-60126 Ancona, Italy
[2] Univ Naples Federico II, Dept Clin Med & Surg, Endocrinol Sect, Naples, Italy
[3] IRCCS SDN, I-80143 Naples, Italy
来源：
ENDOCRINE JOURNAL | 2015年 / 62卷 / 12期
关键词：
Growth hormone; Deficiency; Cardiovascular risk factor; Pituitary; Hormonal treatment; GH-REPLACEMENT THERAPY; IMPROVES BODY-COMPOSITION; QUALITY-OF-LIFE; CURED ACROMEGALIC PATIENTS; DUTCH NATIONAL REGISTRY; HYPOPITUITARY ADULTS; ENDOTHELIAL FUNCTION; ELDERLY-PATIENTS; PLASMINOGEN-ACTIVATOR; PREMATURE MORTALITY;
D O I：
10.1507/endocrj.EJ15-0337
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Adult growth hormone deficiency (GBD) is a well defined clinical condition, which is characterized by abnormal body composition, impaired physical activity and decreased quality of life. In addition, in recent years, growing interest has been shown towards cardiovascular risks in adult patients affected by GHD. In this regard, GHD is widely known to be associated with increased mortality, likely due to the increase of risk factors, such as central obesity, impaired lipid and glucose profiles and other less-known risk factors, such as inflammatory cytokines, endothelial dysfunction and oxidative stress. However, very few papers have recently discussed this topic. In this review, the aim is to clarify this issue bY discussing evidence regarding the effects of adult GHD on metabolic and cardiovascular profiles.
引用
收藏
页码：1037 / 1048
页数：12
相关论文
共 115 条
[1]   Coronary risk in growth hormone deficient hypopituitary adults: increased predicted risk is due largely to lipid profile abnormalities [J].
Abdu, TAM ;
Neary, R ;
Elhadd, TA ;
Akber, M ;
Clayton, RN .
CLINICAL ENDOCRINOLOGY, 2001, 55 (02) :209-216
[2]   Prevalence of diabetes mellitus in 6050 hypopituitary patients with adult-onset GH deficiency before GH replacement: a KIMS analysis [J].
Abs, Roger ;
Mattsson, Anders F. ;
Thunander, Maria ;
Verhelst, Johan ;
Goth, Miklos I. ;
Wilton, Patrick ;
Koltowska-Haggstrom, Maria ;
Luger, Anton .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2013, 168 (03) :297-305
[3]   Fasting and postprandial lipid abnormalities in hypopituitary women receiving conventional replacement therapy [J].
AlShoumer, KAS ;
Cox, KH ;
Hughes, CL ;
Richmond, W ;
Johnston, DG .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (08) :2653-2659
[4]   BODY-COMPOSITION, BONE METABOLISM, AND HEART STRUCTURE AND FUNCTION IN GROWTH-HORMONE (GH)DEFICIENT ADULTS BEFORE AND AFTER GH REPLACEMENT THERAPY AT LOW-DOSES [J].
AMATO, G ;
CARELLA, C ;
FAZIO, S ;
LAMONTAGNA, G ;
CITTADINI, A ;
SABATINI, D ;
MARCIANOMONE, C ;
SACCA, L ;
BELLASTELLA, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 77 (06) :1671-1676
[5]   Recombinant growth hormone (GH) therapy in GH-deficient adults:: A long-term controlled study on daily versus thrice weekly injections [J].
Amato, G ;
Mazziotti, G ;
Di Somma, C ;
Lalli, E ;
De Felice, G ;
Conte, M ;
Rotondi, M ;
Pietrosante, M ;
Lombardi, G ;
Bellastella, A ;
Carella, C ;
Colao, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (10) :3720-3725
[6]   TNF-α levels in children with growth hormone deficiency and the effect of long-term growth hormone replacement therapy [J].
Andiran, Nesibe ;
Yordam, Nursen .
GROWTH HORMONE & IGF RESEARCH, 2007, 17 (02) :149-153
[7]   Cardiac function in growth hormone deficient patients before and after 1 year with replacement therapy: a magnetic resonance imaging study [J].
Andreassen, Mikkel ;
Faber, Jens ;
Kjaer, Andreas ;
Petersen, Claus Leth ;
Kristensen, Lars Ostergaard .
PITUITARY, 2011, 14 (01) :1-10
[8]   Prevalence of Metabolic Syndrome in Adult Hypopituitary Growth Hormone (GH)-Deficient Patients Before and After GH Replacement [J].
Attanasio, Andrea F. ;
Mo, Daojun ;
Erfurth, Eva Marie ;
Tan, Meng ;
Ho, Ken Y. ;
Kleinberg, David ;
Zimmermann, Alan G. ;
Chanson, Philippe .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (01) :74-81
[9]   The effect of hypopituitarism on life expectancy [J].
Bates, AS ;
VantHoff, W ;
Jones, PJ ;
Clayton, RN .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (03) :1169-1172
[10]  
Biller BMK, 2002, J CLIN ENDOCR METAB, V87, P2067, DOI 10.1210/jc.87.5.2067
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