The Genetics of Major Depression

被引：14

作者：

Flint, Jonathan ^{[1
]}

Kendler, Kenneth S. ^{[2
]}

机构：

[1] Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[2] Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Dept Psychiat, Richmond, VA 23298 USA

来源：

NEURON | 2014年 / 81卷 / 03期

基金：

英国惠康基金;

关键词：

GENOME-WIDE ASSOCIATION; SEROTONIN TRANSPORTER GENE; STRESSFUL LIFE EVENTS; GENERALIZED ANXIETY DISORDER; CONVERTING ENZYME GENE; 1A RECEPTOR GENE; BODY-MASS INDEX; BIPOLAR DISORDER; MOOD DISORDERS; SIGNIFICANT LINKAGE;

D O I：

10.1016/j.neuron.2014.01.027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Major depression is the commonest psychiatric disorder and in the U. S. has the greatest impact of all biomedical diseases on disability. Here we review evidence of the genetic contribution to disease susceptibility and the current state of molecular approaches. Genome-wide association and linkage results provide constraints on the allele frequencies and effect sizes of susceptibility loci, which we use to interpret the voluminous candidate gene literature. We consider evidence for the genetic heterogeneity of the disorder and the likelihood that subtypes exist that represent more genetically homogenous conditions than have hitherto been analyzed.

引用

页码：484 / 503

页数：20

共 166 条

[1] Predisposition locus for major depression at chromosome 12q22-12q23.2 [J].

Abkevich, V ;

Camp, NJ ;

Hensel, CH ;

Neff, CD ;

Russell, DL ;

Hughes, DC ;

Plenk, AM ;

Lowry, MR ;

Richards, RL ;

Carter, C ;

Frech, GC ;

Stone, S ;

Rowe, K ;

Chau, CA ;

Cortado, K ;

Hunt, A ;

Luce, K ;

O'Neil, G ;

Poarch, J ;

Potter, J ;

Poulsen, GH ;

Saxton, H ;

Bernat-Sestak, M ;

Thompson, V ;

Gutin, A ;

Skolnick, MH ;

Shattuck, D ;

Cannon-Albright, L .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (06) :1271-1281

[2] DEPRESSIVE DISORDERS - TOWARD A UNIFIED HYPOTHESIS [J].

AKISKAL, HS ;

MCKINNEY, WT .

SCIENCE, 1973, 182 (4107) :20-29

[3] Hundreds of variants clustered in genomic loci and biological pathways affect human height [J].

Allen, Hana Lango ;

Estrada, Karol ;

Lettre, Guillaume ;

Berndt, Sonja I. ;

Weedon, Michael N. ;

Rivadeneira, Fernando ;

Willer, Cristen J. ;

Jackson, Anne U. ;

Vedantam, Sailaja ;

Raychaudhuri, Soumya ;

Ferreira, Teresa ;

Wood, Andrew R. ;

Weyant, Robert J. ;

Segre, Ayellet V. ;

Speliotes, Elizabeth K. ;

Wheeler, Eleanor ;

Soranzo, Nicole ;

Park, Ju-Hyun ;

Yang, Jian ;

Gudbjartsson, Daniel ;

Heard-Costa, Nancy L. ;

Randall, Joshua C. ;

Qi, Lu ;

Smith, Albert Vernon ;

Maegi, Reedik ;

Pastinen, Tomi ;

Liang, Liming ;

Heid, Iris M. ;

Luan, Jian'an ;

Thorleifsson, Gudmar ;

Winkler, Thomas W. ;

Goddard, Michael E. ;

Lo, Ken Sin ;

Palmer, Cameron ;

Workalemahu, Tsegaselassie ;

Aulchenko, Yurii S. ;

Johansson, Asa ;

Zillikens, M. Carola ;

Feitosa, Mary F. ;

Esko, Tonu ;

Johnson, Toby ;

Ketkar, Shamika ;

Kraft, Peter ;

Mangino, Massimo ;

Prokopenko, Inga ;

Absher, Devin ;

Albrecht, Eva ;

Ernst, Florian ;

Glazer, Nicole L. ;

Hayward, Caroline .

NATURE, 2010, 467 (7317) :832-838

[4]

Alonso J, 2004, ACTA PSYCHIAT SCAND, V109, P38

[5]

Alonso J, 2004, ACTA PSYCHIAT SCAND, V109, P28

[6] A map of human genome variation from population-scale sequencing [J].

Altshuler, David ;

Durbin, Richard M. ;

Abecasis, Goncalo R. ;

Bentley, David R. ;

Chakravarti, Aravinda ;

Clark, Andrew G. ;

Collins, Francis S. ;

De la Vega, Francisco M. ;

Donnelly, Peter ;

Egholm, Michael ;

Flicek, Paul ;

Gabriel, Stacey B. ;

Gibbs, Richard A. ;

Knoppers, Bartha M. ;

Lander, Eric S. ;

Lehrach, Hans ;

Mardis, Elaine R. ;

McVean, Gil A. ;

Nickerson, DebbieA. ;

Peltonen, Leena ;

Schafer, Alan J. ;

Sherry, Stephen T. ;

Wang, Jun ;

Wilson, Richard K. ;

Gibbs, Richard A. ;

Deiros, David ;

Metzker, Mike ;

Muzny, Donna ;

Reid, Jeff ;

Wheeler, David ;

Wang, Jun ;

Li, Jingxiang ;

Jian, Min ;

Li, Guoqing ;

Li, Ruiqiang ;

Liang, Huiqing ;

Tian, Geng ;

Wang, Bo ;

Wang, Jian ;

Wang, Wei ;

Yang, Huanming ;

Zhang, Xiuqing ;

Zheng, Huisong ;

Lander, Eric S. ;

Altshuler, David L. ;

Ambrogio, Lauren ;

Bloom, Toby ;

Cibulskis, Kristian ;

Fennell, Tim J. ;

Gabriel, Stacey B. .

NATURE, 2010, 467 (7319) :1061-1073

[7] COMORBIDITY OF ANXIETY, PHOBIA, COMPULSION AND DEPRESSION [J].

ANGST, J .

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 1993, 8 :21-25

[8] Prevalence and Characteristics of Undiagnosed Bipolar Disorders in Patients With a Major Depressive Episode The BRIDGE Study [J].

Angst, Jules ;

Azorin, Jean-Michel ;

Bowden, Charles L. ;

Perugi, Giulio ;

Vieta, Eduard ;

Gamma, Alex ;

Young, Allan H. .

ARCHIVES OF GENERAL PSYCHIATRY, 2011, 68 (08) :791-799

[9] Major Depressive Disorder With Subthreshold Bipolarity in the National Comorbidity Survey Replication [J].

Angst, Jules ;

Cui, Lihong ;

Swendsen, Joel ;

Rothen, Stephane ;

Cravchik, Anibal ;

Merikangas, Kathleen R. .

AMERICAN JOURNAL OF PSYCHIATRY, 2010, 167 (10) :1194-1201

[10] A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders [J].

Anguelova, M ;

Benkelfat, C ;

Turecki, G .

MOLECULAR PSYCHIATRY, 2003, 8 (06) :574-591

← 1 2 3 4 5 6 7 8 9 10 →