Cholesterol lowering and mortality: Time for a new paradigm?

被引：9

作者：

de Lorgeril, Michel ^{[1
]}

Salen, Patricia ^{[1
]}

机构：

[1] Fac Med, Lab Nutr Vieillissement & Malad Cardiovasc, F-38056 Grenoble, France

来源：

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 2006年 / 16卷 / 06期

关键词：

cholesterol; statins; sudden cardiac death; myocardial infarction; mortality;

D O I：

10.1016/j.numecd.2006.05.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sudden cardiac death is the main cause of cardiac mortality. Is blood cholesterol a determinant of sudden cardiac death? Does cholesterol lowering result in fewer sudden cardiac deaths? Answering these two questions may shed new light on the epidemiology of coronary heart disease and on prevention options. In fact, careful analysis of the available data, including randomised trials, indicates that, contrary to a widespread opinion, cholesterol Lowering does not appear to be a very effective way of reducing cardiac and overall mortality in the general population. (C) 2006 Elsevier B.V. All rights reserved.

引用

页码：387 / 390

页数：4

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