Synthesis and anti-angiogenesis activity of coumarin derivatives

被引：140

作者：

Lee, Seokjoon ^{[1
]}

Sivakumar, Krishnamoorthy

Shin, Woon-Seob

Xie, Fang

Wang, Qian

机构：

[1] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29203 USA

[2] Kwangdong Univ, Coll Med, Dept Basic Sci, Kangnung 210701, South Korea

[3] Kwangdong Univ, Coll Med, Dept Microbiol, Kangnung 210701, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 17期

关键词：

coumarin derivaties; angiogenesis; anti-angigenesis; fluorescence; synthesis; small molecule; imaging;

D O I：

10.1016/j.bmcl.2006.06.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 7-diethylaminocoumarin compounds were synthesized and the cytotoxicities were tested against human umbilical vein endothelial cell (HUVEC) and some cancer cells. We found that the introduction of cyano groups at the 4-position will promote the bioactivity. In particular, compounds 9 and 10 strongly inhibited the proliferation of various cancer cell lines, and 12 and 15 showed a high selectivity for HUVEC. Therefore, these coumarin molecules can be utilized as lead compounds to develop potential nontoxic angiogenesis inhibitors and small molecular ligands to target HUVEC. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4596 / 4599

页数：4

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