RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates

被引:54
作者
Nayak, Arabinda [1 ]
Tassetto, Michel [1 ]
Kunitomi, Mark [1 ]
Andino, Raul [1 ]
机构
[1] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94122 USA
来源
INTRINSIC IMMUNITY | 2013年 / 371卷
关键词
MESSENGER-RNA; VIRUS-REPLICATION; AEDES-ALBOPICTUS; SYSTEMIC RNAI; PROTEIN; INFECTION; DICER-2; SIRNA; SUPPRESSION; MICRORNAS;
D O I
10.1007/978-3-642-37765-5_7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In invertebrates such as insects and nematodes, RNA interference (RNAi) provides RNA-based protection against viruses. This form of immunity restricts viral replication and dissemination from infected cells and viruses, in turn, have evolved evasion mechanisms or RNAi suppressors to counteract host defenses. Recent advances indicate that, in addition to RNAi, other related small RNA pathways contribute to antiviral functions in invertebrates. This has led to a deeper understanding of fundamental aspects of small RNA-based antiviral immunity in invertebrates and its contribution to viral spread and pathogenesis.
引用
收藏
页码:183 / 200
页数:18
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