Two new labdane diterpenoids from aerial parts of Leonurus japonicus and their anti-inflammatory activity

被引：12

作者：

Hu, Yu-Mei ^{[1
,2
,3
,4
]}

Liu, Wen-Jun ^{[2
,3
]}

Li, Meng-Xuan ^{[2
,3
]}

Li, Hai-Bo ^{[2
,3
]}

Jiang, Tao ^{[2
,3
]}

Cheng, Ning-Bo ^{[1
,2
,3
]}

Huang, Wen-Zhe ^{[2
,3
]}

Wang, Zhen-Zhong ^{[2
,3
]}

Zhu, Hua-Xu ^{[1
,4
]}

Xiao, Wei ^{[2
,3
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Nanjing, Jiangsu, Peoples R China

[2] Jiangsu Kanion Pharmaceut Co Ltd, Lianyungang, Peoples R China

[3] State Key Lab New Tech Chinese Med Pharmaceut Pro, Lianyungang, Peoples R China

[4] Nanjing Univ Chinese Med, Jiangsu Bot Med Refine Engn Res Ctr, Nanjing, Jiangsu, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 17期

关键词：

Leonurus japonicus; labdane diterpenoids; ECD; anti-inflammatory activity; INHIBITORY-ACTIVITY; GLYCOSIDES;

D O I：

10.1080/14786419.2018.1455040

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new labdane diterpenoids, Leojaponin E (1) and F (2), together with three known compounds were isolated from the dried herb of Leonurus japonicus Houtt., Lamiaceae. Their structures were determined based on extensive spectroscopic analyses. The absolute configurations of 1 and 2 were elucidated on the basis of experimental and calculated electronic circular dichroism spectra. In addition, compounds 1 and 2 exerted inhibition of LPS-induced PGE(2) production in a dose-dependent manner at concentrations ranging from 5 to 20 mu M. [GRAPHICS] .

引用

页码：2490 / 2497

页数：8

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