Interaction of foot-and-mouth disease virus with dendritic cells

被引：5

作者：

Bayry, Jagadeesh

Tough, David F.

机构：

[1] Univ Oxford, Edward Jenner Inst Vaccine Res, Newbury RG20 7NN, Berks, England

[2] Univ Paris 06, Inst Biomed Cordeliers, F-75006 Paris, France

来源：

TRENDS IN MICROBIOLOGY | 2006年 / 14卷 / 08期

关键词：

D O I：

10.1016/j.tim.2006.06.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite several decades of investigation, the manner in which foot-and-mouth disease virus (FMDV) interacts with the innate and adaptive immune compartments is not completely understood. The importance of elucidating this relationship is emphasized by the inability of current FMDV vaccines to provide long-term protection and the recent outbreaks of FMDV in formerly disease-free countries. Dendritic cells (DCs) are professional antigen-presenting cells that have evolved to monitor the environment and provide a link between the innate and adaptive immune systems. Comprehending the cross-talk between DC and FMDV will provide valuable information towards understanding the host response to the virus and will aid in the design of effective tools and vaccines to block virus spread.

引用

收藏

页码：346 / 347

页数：2

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