A Century of Heparin

被引：10

作者：

Ong, Chin Siang ^{[1
,2
]}

Marcum, James A. ^{[3
]}

Zehr, Kenton J. ^{[1
]}

Cameron, Duke E. ^{[2
]}

机构：

[1] Johns Hopkins Univ Hosp, Div Cardiac Surg, Baltimore, MD 21287 USA

[2] Massachusetts Gen Hosp, Div Cardiac Surg, 55 Fruit St,Cox 630, Boston, MA 02114 USA

[3] Baylor Univ, Dept Philosophy, Med Humanities Program, Waco, TX 76798 USA

来源：

ANNALS OF THORACIC SURGERY | 2019年 / 108卷 / 03期

关键词：

DISCOVERY; PURIFICATION; MCLEAN; JAY; STORY;

D O I：

10.1016/j.athoracsur.2019.03.104

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The year 2018 was the centennial of the naming of heparin by Emmett Holt and William Howell and the 102nd anniversary of Jay McLean's discovery of an anticoagulant heparphosphatide at Johns Hopkins Hospital in Baltimore. This article discusses recently discovered historical artifacts that shed new light on heparin's christening, including McLean's unpublished letter written in 1950 that represents one of the most complete accounts of heparin's discovery before his untimely death. In addition, the article describes the finding of a plaque dedicated to McLean and explores the circumstances of its removal from public display, as learned from interviews with present and former staff members. (C) 2019 by The Society of Thoracic Surgeons

引用

页码：955 / 958

页数：4

共 25 条

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