Confinement and controlled release of bisphosphonates on ordered mesoporous silica-based materials

被引：369

作者：

Balas, Francisco ^{[1
]}

Manzano, Miguel ^{[1
]}

Horcajada, Patricia ^{[1
]}

Vallet-Regi, Maria ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Farm, Dept Quim Inorgan & Bioinorgan, E-28040 Madrid, Spain

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 25期

关键词：

D O I：

10.1021/ja062286z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bisphosphonates have been confined in siliceous ordered mesoporous materials, and the drug release rate of these systems has been investigated. The bisphosphonate adsorption rate has been increased from 1% in oral administration to around 40% locally delivered. Drug dosage can be modulated through amine modification of the material surface, leading to a bisphosphonate adsorption in the ordered mesoporous matrices 3 times larger than that for unmodified materials. The use of these drug delivery systems opens new fields with new possibilities for tissue engineering. Copyright © 2006 American Chemical Society.

引用

页码：8116 / 8117

页数：2

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