Impaired tolerance to repetitive hypoxia in hippocampal slices of Cu,Zn superoxide dismutase transgenic mice

被引：9

作者：

Büchner, M ^{[1
]}

Li, HG ^{[1
]}

Huber, R ^{[1
]}

Timmler, M ^{[1
]}

Sehrsam, I ^{[1
]}

Kasischke, K ^{[1
]}

Völkel, H ^{[1
]}

Ludolph, AC ^{[1
]}

Riepe, MW ^{[1
]}

机构：

[1] Univ Ulm, Dept Neurol, D-89075 Ulm, Germany

来源：

NEUROSCIENCE LETTERS | 1999年 / 276卷 / 02期

关键词：

amyotrophic lateral sclerosis; hypoxic tolerance; chemical preconditioning; hippocampal slice; C57B6SJL; TgN(SOD1-G93A)1GUR mice;

D O I：

10.1016/S0304-3940(99)00808-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Energy metabolism is impaired in the Cu,Zn superoxide dismutase transgenic mouse model of amyotrophic lateral sclerosis. The goal was to investigate tolerance against single and repetitive hypoxia in C57BGSJL-TSN(SOD1-G93A)1GUR mice (G93A mice). Posthypoxic recovery (15 min hypoxia, 45 min recovery) of population spike amplitude in hippocampal region CA1 was 38 +/- 29% (mean +/- SD) in controls and 67 +/- 41% (ns) in G93A mice at day 40. Upon in vivo pretreatment with 20 mg/kg 3-nitropropionate posthypoxic recovery increased to 82 +/- 32% (P < 0.01) in controls and decreased to 35 +/- 33% in G93A mice (P < 0.05 to pretreated controls). Results at day 80 and 110 were similar. We conclude that G93A mice show a long-lasting impairment to sustain repetitive hypoxic episodes whereas tolerance to a single hypoxic episode is comparable to controls. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：131 / 134

页数：4

共 19 条

[1]

Browne SE, 1998, J NEUROCHEM, V71, P281

[2] Expression of a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis induces mitochondrial alteration and increase of cytosolic Ca2+ concentration in transfected neuroblastoma SH-SY5Y cells [J].