Should organs from hepatitis C-positive donors be used in hepatitis C-negative recipients for liver transplantation?

被引：30

作者：

Selzner, Nazia ^{[1
]}

Berenguer, Marina ^{[2
]}

机构：

[1] Univ Toronto, Multiorgan Transplant Program, Toronto, ON, Canada

[2] Univ Valencia, La Fe Univ Hosp, Liver Transplantat & Hepatol Unit, Valencia, Spain

来源：

LIVER TRANSPLANTATION | 2018年 / 24卷 / 06期

关键词：

ACTING ANTIVIRAL AGENTS; TERM-FOLLOW-UP; VIRUS-INFECTION; UNITED-STATES; GENOTYPE; HCV; CLEARANCE; ANTIBODY; OUTCOMES; RISK;

D O I：

10.1002/lt.25072

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Given the scarcity of donated organs and the frequency of death on the waiting list, strategies that could improve the available supply of high-quality liver grafts are much needed. Direct-acting antiviral agent (DAA) regimens have proved to be highly effective to treat hepatitis C virus (HCV), even in the setting of posttransplantation. The question arises as to whether transplant communities should consider the utilization of HCV-positive donors into HCV-negative recipients. This review summarizes risk of transmission, treatment options with success rate, and ethical considerations for usage of HCV-positive donors. Liver Transplantation 24 831-840 2018 AASLD.

引用

页码：831 / 840

页数：10

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