Phosphorylation of G3BP1-S149 does not influence stress granule assembly

被引：36

作者：

Panas, Marc D. ^{[1
,2
,3
]}

Kedersha, Nancy ^{[1
,2
]}

Schulte, Tim ^{[4
]}

Branca, Rui M. ^{[5
]}

Ivanov, Pavel ^{[1
,2
]}

Anderson, Paul ^{[1
,2
]}

机构：

[1] Harvard Med Sch, Div Rheumatol Immunol & Allergy, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[3] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden

[4] Karolinska Inst, Dept Med Solna, Sci Life Lab, Stockholm, Sweden

[5] Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, Clin Prote Mass Spectrometry, Stockholm, Sweden

来源：

JOURNAL OF CELL BIOLOGY | 2019年 / 218卷 / 07期

基金：

美国国家卫生研究院;

关键词：

MEDIATE;

D O I：

10.1083/jcb.201801214

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tourriere et al. (2013. J. Cell Biol. https://doi.org/10.1083/jcb.200212128) reported that G3BP1-S149 dephosphorylation promotes stress granule formation. We show that constructs used to establish this conclusion contain additional mutations causing these phenotypes, and that S149 phosphorylation status does not change upon stress.

引用

页码：2425 / 2432

页数：8

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