The microbiome modulates arbovirus transmission in mosquitoes

被引:141
作者
Hegde, Shivanand [1 ]
Rasgon, Jason L. [2 ,3 ,4 ]
Hughes, Grant L. [1 ,5 ]
机构
[1] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA
[2] Penn State Univ, Dept Entomol, University Pk, PA 16802 USA
[3] Penn State Univ, Huck Inst Life Sci, University Pk, PA 16802 USA
[4] Penn State Univ, Ctr Infect Dis Dynam, University Pk, PA 16802 USA
[5] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 USA
关键词
HOST GENE-EXPRESSION; JAK-STAT PATHWAY; AEDES-AEGYPTI; DENGUE VIRUS; SYMBIOTIC BACTERIA; VECTOR COMPETENCE; GUT MICROBIOTA; WOLBACHIA; ALBOPICTUS; ASAIA;
D O I
10.1016/j.coviro.2015.08.011
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Mosquito-transmitted arthropod-borne viruses (arboviruses) such as dengue virus, chikungunya virus, and West Nile virus constitute a major public health burden and are increasing in severity and frequency worldwide. The microbiota associated with mosquitoes (comprised of viruses, bacteria, fungi and protozoa) can profoundly influence many host phenotypes including vector competence, which can either be enhanced or suppressed. Thus, the tripartite interactions between the mosquito vector, its microbiota and the pathogens they transmit offer novel possibilities to control arthropod-borne diseases.
引用
收藏
页码:97 / 102
页数:6
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