Gene encoding protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer

被引：201

作者：

Anand, N

Murthy, S

Amann, G

Wernick, M

Porter, LA

Cukier, IH

Collins, C

Gray, JW

Diebold, J

Demetrick, DJ

Lee, JM

机构：

[1] Hamilton Reg Canc Ctr, Hamilton, ON L8V 5C2, Canada

[2] Univ Calgary, Dept Pathol, Calgary, AB, Canada

[3] Univ Calgary, Dept Oncol, Calgary, AB, Canada

[4] Univ Calgary, Dept Med Biochem, Calgary, AB, Canada

[5] Univ Munich, Inst Pathol, D-8000 Munich, Germany

[6] Univ Calif San Francisco, Ctr Canc, San Francisco, CA 94143 USA

[7] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada

来源：

NATURE GENETICS | 2002年 / 31卷 / 03期

关键词：

D O I：

10.1038/ng904

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have found that EEF1A2, the gene encoding protein elongation factor EEF1A2 (also known as eEF-1alpha2), is amplified in 25% of primary ovarian tumors and is highly expressed in approximately 30% of ovarian tumors and established cell lines. We have also demonstrated that EEF1A2 has oncogenic properties: it enhances focus formation, allows anchorage-independent growth and decreases the doubling time of rodent fibroblasts. In addition, EEF1A2 expression made NIH3T3 fibroblasts tumorigenic and increased the growth rate of ES-2 ovarian carcinoma cells xenografted in nude mice. Thus, EEF1A2 and the process of protein elongation are likely to be critical in the development of ovarian cancer.

引用

页码：301 / 305

页数：5

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