Outcomes of patients with interstitial lung disease referred for lung transplant assessment

被引:6
作者
Reed, A.
Snell, G. I.
McLean, C.
Williams, T. J.
机构
[1] Alfred Hosp, Dept Allergy Immunol & Resp Med, Melbourne, Vic 3004, Australia
[2] Alfred Hosp, Dept Anat Pathol, Melbourne, Vic 3004, Australia
[3] Monash Univ, Melbourne, Vic 3004, Australia
关键词
interstitial lung disease; pulmonary fibrosis; usual interstitial pneumonia; lung transplantation;
D O I
10.1111/j.1445-5994.2006.01103.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Patients with interstitial lung disease (ILD) very frequently die before the opportunity to receive lung transplantation (LTx). This retrospective study describes the clinical course of 86 patients with ILD referred for LTx assessment between January 1999 and December 2002. Aims: (i) To describe the outcomes, (ii) to identify reasons of delay to transplantation, (iii) to describe the causes of death/complications and (iv) to assess the pathological diagnosis and concordance with explanted lung pathology. Methods: Data were collected from the case notes of all patients with ILD referred to the Alfred Hospital over a 4-year period. Results: Twenty women and 66 men, mean age of 55 +/- 8 years, were referred for LTx assessment. Forty-five patients were deemed not suitable for LTx and 41 were listed. Twenty-two patients underwent transplantation, 16 died on the waiting list and 7 are still on the waiting list. Complications were frequent (e.g. pulmonary embolism, malignancy and infection) and carried high mortality. Patients dying on the waiting list appeared generally to be in accelerated decline, dying shortly after listing, with no evidence in their lung function test assessment predicting them as a poor prognosis group. Conclusions: Serious complications and death on the waiting list of patients with idiopathic pulmonary fibrosis are high, not apparently because of delayed referral but usually in patients undergoing very rapid decline.
引用
收藏
页码:423 / 430
页数:8
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