Improved 19F{1H} Saturation Transfer Difference Experiments for Sensitive Detection to Fluorinated Compound Bound to Proteins

被引：1

作者：

Furihata, Kazuo ^{[1
]}

Tashiro, Mitsuru ^{[2
]}

机构：

[1] Univ Tokyo, Div Agr & Agr Life Sci, Bunkyo Ku, Tokyo 1138657, Japan

[2] Meisei Univ, Coll Sci & Technol, Dept Chem, Tokyo 1918506, Japan

来源：

MAGNETOCHEMISTRY | 2019年 / 5卷 / 01期

关键词：

NMR-based screening; fluorinated compound; diflunisal; F-19; NMR; shaped pulses; BINDING-AFFINITY; NMR; IDENTIFICATION; RANGE;

D O I：

10.3390/magnetochemistry5010001

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The F-19{H-1} saturation transfer difference (STD) method was improved for sensitive F-19 detection using a human serum albumin-diflunisal complex. Because NMR (nuclear magnetic resonance) experiments with F-19 detection are feasible for the selective detection of fluorinated compounds, more sensitive NMR methods are required to be developed for purposes of practicality. The present research focused on the investigations of F-19{H-1} STD pulse techniques and experimental parameters, leading to the development of detection methods with higher sensitivity.

引用

页数：6

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