Antifungal Drug Development: Challenges, Unmet Clinical Needs, and New Approaches

被引：388

作者：

Roemer, Terry ^{[1
]}

Krysan, Damian J. ^{[2
,3
]}

机构：

[1] Merck Res Labs, Infect Dis Res, Kenilworth, NJ 07033 USA

[2] Univ Rochester, Dept Pediat, Rochester, NY 14642 USA

[3] Univ Rochester, Dept Microbiol & Immunol, Rochester, NY 14642 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2014年 / 4卷 / 05期

基金：

美国国家卫生研究院;

关键词：

GLUCAN SYNTHASE INHIBITOR; TRANSFER-RNA SYNTHETASE; AMPHOTERICIN-B; CRYPTOCOCCAL MENINGITIS; FUNGAL-INFECTIONS; BAD BUGS; DISCOVERY; EFFICACY; YEAST; SUSCEPTIBILITY;

D O I：

10.1101/cshperspect.a019703

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Invasive, life-threatening fungal infections are an important cause of morbidity and mortality, particularly for patients with compromised immune function. The number of therapeutic options for the treatment of invasive fungal infections is quite limited when compared with those available to treat bacterial infections. Indeed, only three classes of molecules are currently used in clinical practice and only one new class of antifungal drugs has been developed in the last 30 years. Here we summarize the unmet clinical needs of current antifungal therapy, discuss challenges inherent to antifungal drug discovery and development, and review recent developments aimed at addressing some of these challenges.

引用

页数：14

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