Computation of residence time in the simulation of pulsatile ventricular assist devices

被引：79
作者：
Long, C. C. [2 ]
Esmaily-Moghadam, M. [2 ]
Marsden, A. L. [2 ]
Bazilevs, Y. [1 ]
机构：
[1] Univ Calif San Diego, Dept Struct Engn, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Mech & Aerosp Engn, La Jolla, CA 92093 USA
来源：
COMPUTATIONAL MECHANICS | 2014年 / 54卷 / 04期
关键词：
PVAD; Residence time; FSI; Isogeometric analysis; Biomechanics; FEM; Blood flow; FLUID-STRUCTURE INTERACTION; FINITE-ELEMENT COMPUTATION; DERIVATIVE-FREE OPTIMIZATION; STAGNATION POINT FLOW; PLATELET DEPOSITION; CONSTRAINED OPTIMIZATION; ISOGEOMETRIC ANALYSIS; BLOOD-FLOW; FORMULATION; ALGORITHMS;
D O I：
10.1007/s00466-013-0931-y
中图分类号：
O1 [数学];
学科分类号：
0701 ; 070101 ;
摘要：
A continuum-based model of particle residence time for moving-domain fluid mechanics and fluid-structure interaction (FSI) computations is proposed, analyzed, and applied to the simulation of an adult pulsatile ventricular assist device (PVAD). Residence time is a quantity of clinical interest for blood pumps because it correlates with thrombotic risk. The proposed technique may be easily implemented in any flow or FSI solver. In the context of PVADs the results of the model may be used to assess how efficiently the pump moves the blood through its interior. Three scalar measures of particle residence time are also proposed. These scalar quantities may be used in the PVAD design with the goal of reducing thrombotic risk.
引用
收藏
页码：911 / 919
页数：9
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