Diadenylated polyols as new non-isopolar analogues of diadenosine tri- and tetraphosphates

被引:16
作者
Baraniak, J [1 ]
Wasilewska, E [1 ]
Korczynski, D [1 ]
Stec, WJ [1 ]
机构
[1] Polish Acad Sci, Ctr Mol & Macromol Studies, Dept Bioorgan Chem, PL-90363 Lodz, Poland
关键词
phosphorothioylation; polyols; oxathiaphospholanes ring-opening condensation;
D O I
10.1016/S0040-4039(99)01802-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A series of diadenosine polyphosphate-mimics were prepared based upon phosphorothioylation of the hydroxyl functions of polyols 1 and 1,3,2-oxathiaphospholane ring-opening condensation methodology. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:8603 / 8606
页数:4
相关论文
共 17 条
[1]   Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5'''-P-1,P-3-triphosphate hydrolase [J].
Barnes, LD ;
Garrison, PN ;
Siprashvili, Z ;
Guranowski, A ;
Robinson, AK ;
Ingram, SW ;
Croce, CM ;
Ohta, M ;
Huebner, F .
BIOCHEMISTRY, 1996, 35 (36) :11529-11535
[2]  
BLACKBURN GM, 1981, CHEM IND-LONDON, P134
[3]   P-1,P-4-dithio-P-2,P-3-monochloromethylene diadenosine 5',5'''-P-1,P-4-tetraphosphate: A novel antiplatelet agent [J].
Chan, SW ;
Gallo, SJ ;
Kim, BK ;
Guo, MJ ;
Blackburn, GM ;
Zamecnik, PC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) :4034-4039
[4]  
Druck T, 1997, CANCER RES, V57, P504
[5]  
GURANOWSKI A, UNPUB
[6]   ANTITHROMBOTIC EFFECT OF BETA,BETA'-MONOCHLOROMETHYLENE DIADENOSINE 5',5'''-P(1),P(4)-TETRAPHOSPHATE [J].
KIM, BK ;
ZAMECNIK, P ;
TAYLOR, G ;
GUO, MJ ;
BLACKBURN, GM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (22) :11056-11058
[7]  
Liu XH, 1999, ANGEW CHEM INT EDIT, V38, P1244, DOI 10.1002/(SICI)1521-3773(19990503)38:9<1244::AID-ANIE1244>3.0.CO
[8]  
2-0
[9]   Synthesis of novel 'supercharged' analogues of pyrophosphoric acid [J].
Liu, XH ;
Adams, H ;
Blackburn, GM .
CHEMICAL COMMUNICATIONS, 1998, (23) :2619-2620
[10]  
McLennan A. G., 1992, AP4A OTHER DINUCLEOS