Epstein-Barr virus entry utilizing HLA-DP or HLA-DQ as a coreceptor

被引：97

作者：

Haan, KM

Kwok, WW

Longnecker, R

Speck, P

机构：

[1] Northwestern Univ, Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA

[2] Virginia Mason Res Ctr, Seattle, WA 98101 USA

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 05期

关键词：

D O I：

10.1128/JVI.74.5.2451-2454.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Epstein-Barr virus (EBV) glycoprotein gp350/gp220 association with cellular CD21 facilitates virion attachment to B lymphocytes. Membrane fusion requires the additional interaction between virion gp42 and cellular HLA-DR. This binding is thought to catalyze membrane fusion through a further association with the gp85-gp25 (gH-gL) complex. Cell lines expressing CD21 but lacking expression of HLA class II molecules are resistant to infection by a recombinant EBV expressing enhanced green fluorescent protein. Surface expression of HLA-DR, HLA-DP, or HLA-DQ confers susceptibility to EBV infection on resistant cells that express CD21. Therefore, HLA-DP or HLA-DQ can substitute for HLA-DR and:serve as a coreceptor in EBV entry.

引用

收藏

页码：2451 / 2454

页数：4

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