Laccase/TEMPO-mediated system for the thermodynamically disfavored oxidation of 2,2-dihalo-1-phenylethanol derivatives

被引：46

作者：

Alba Diaz-Rodriguez, Kinga Kedziora ^{[1
]}

Lavandera, Ivan ^{[1
]}

Gotor-Fernandez, Vicente ^{[1
]}

Gotor, Vicente ^{[1
]}

机构：

[1] Univ Oviedo, Inst Univ Biotecnol Asturias, Dept Quim Organ & Inorgan, E-33006 Oviedo, Spain

来源：

GREEN CHEMISTRY | 2014年 / 16卷 / 05期

关键词：

DYNAMIC KINETIC RESOLUTION; LIGNIN MODEL; CATALYZED OXIDATION; SECONDARY ALCOHOLS; ORGANIC-SYNTHESIS; EFFICIENT ROUTE; ENZYME LACCASE; TEMPO; RACEMIZATION; KETONES;

D O I：

10.1039/c4gc00066h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient methodology to oxidize beta,beta-dihalogenated secondary alcohols employing oxygen was achieved in a biphasic medium using the laccase from Trametes versicolor/TEMPO pair, providing the corresponding ketones in a clean fashion under very mild conditions. Moreover, a chemoenzymatic protocol has been applied successfully to deracemize 2,2-dichloro-1-phenylethanol combining this oxidation with an alcohol dehydrogenase-catalyzed bioreduction.

引用

页码：2448 / 2453

页数：6

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