One-pot synthesis of N-substituted azapodophyllotoxin derivatives under microwave irradiation

被引：17

作者：

Tu, Shujiang ^{[1
]}

Zhang, Yan

Jiang, Bo

Jia, Runhong

Zhang, Junyong

Zhang, Jinpeng

Ji, Shunjun

机构：

[1] Xuzhou Normal Univ, Dept Chem, Key Lab Biotechnol Med Plant, Xuzhou 221116, Jiangsu, Peoples R China

[2] Suzhou Univ, Coll Chem & Chem Engn, Key Lab Organ Synth Jiangsu Prov, Suzhou 215006, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2006年 / 22期

关键词：

microwave irradiation; tetronic acid; enaminone; N-substituted furo[3,4-b]quinoline; azapodophyllotoxin;

D O I：

10.1055/s-2006-950297

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of new, N-substituted azapodophyllotoxin derivatives were synthesized via a three-component reaction of an aldehyde, an enaminone and tetronic acid in glacial acetic acid, under microwave irradiation, without a catalyst. This new protocol has the advantages of shorter time, higher yields, lower cost and broader substrate scope, as well as easier operation.

引用

页码：3874 / 3882

页数：9

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