Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

被引：1892
作者：
Long, Justin M. [1 ]
Holtzman, David M. [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Neurol,Hope Ctr Neurol Disorders, Charles F & Joanne Knight Alzheimers Dis Res Ctr, St Louis, MO 63110 USA
来源：
CELL | 2019年 / 179卷 / 02期
关键词：
AMYLOID PRECURSOR PROTEIN; TRANSGENIC MOUSE MODEL; CENTRAL-NERVOUS-SYSTEM; SIMPLEX-VIRUS TYPE-1; A-BETA CLEARANCE; RANDOMIZED CONTROLLED-TRIAL; MILD COGNITIVE IMPAIRMENT; PAIRED HELICAL FILAMENTS; ANTI-TAU ANTIBODY; SLOW-WAVE SLEEP;
D O I：
10.1016/j.cell.2019.09.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The presence of extracellular beta-amyloid deposition as neuritic plaques and intracellular accumulation of hyperphosphylated tau as neurofibrillary tangles remaim. the primary neuropathologic criteria for AD diagnosis. However, a number of recent fundamental discoveries highlight important pathological roles for other critical cellular and molecular processes. Despite this, no disease-modifying treatment currently exists, and numerous phase 3 clinical trials have failed to demonstrate benefits. Here, we review recent advances in our understanding of AD pathobiology and discuss current treatment strategies, highlighting recent clinical trials and opportunities for developing future disease-modifying therapies.
引用
收藏
页码：312 / 339
页数：28
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