First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease

被引：93

作者：

Dornemann, Jenny ^{[1
]}

Burzio, Chiara ^{[1
]}

Ronsse, Axelle ^{[1
]}

Sprecher, Armand ^{[1
]}

De Clerck, Hilde ^{[1
]}

Van Herp, Michel ^{[1
]}

Kolie, Marie-Claire ^{[3
]}

Yosifiva, Vesselina ^{[1
]}

Caluwaerts, Severine ^{[1
,2
]}

McElroy, Anita K. ^{[4
,5
]}

Antierens, Annick ^{[1
]}

机构：

[1] Med Sans Frontieres, Brussels, Belgium

[2] Inst Trop Med, Antwerp, Belgium

[3] Med Sans Frontieres, Conakry, Guinea

[4] Ctr Dis Control & Prevent, Atlanta, GA USA

[5] Emory Univ, Div Pediat Infect Dis, Atlanta, GA 30322 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2017年 / 215卷 / 02期

关键词：

Ebola; ZMapp; GS-5734; IMMUNITY;

D O I：

10.1093/infdis/jiw493

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A neonate born to an Ebola virus-positive woman was diagnosed with Ebola virus infection on her first day of life. The patient was treated with monoclonal antibodies (ZMapp), a buffy coat transfusion from an Ebola survivor, and the broad-spectrum antiviral GS-5734. On day 20, a venous blood specimen tested negative for Ebola virus by quantitative reverse-transcription polymerase chain reaction. The patient was discharged in good health on day 33 of life. Further follow-up consultations showed age-appropriate weight gain and neurodevelopment at the age of 12 months. This patient is the first neonate documented to have survived congenital infection with Ebola virus.

引用

页码：171 / 174

页数：4

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