Serum lipid profile and fatty acid composition of erythrocyte phospholipids in children and adolescents with primary hyperlipidemia

被引：6
作者：
Deon, Valeria [1 ]
Del Bo, Cristian [1 ]
Guaraldi, Federica [2 ]
Gargari, Giorgio [3 ]
Bosusco, Andrea [2 ]
Simonetti, Paolo [1 ]
Riso, Patrizia [1 ]
Guardamagna, Ornella [2 ]
机构：
[1] Univ Milan, Div Human Nutr, Dept Food Environm & Nutr Sci, Via G Celoria 2, I-20133 Milan, Italy
[2] Univ Torino, Dept Hlth Sci & Pediat, Turin, Italy
[3] Univ Milan, Div Food Microbiol & Bioproc, Dept Food Environm & Nutr Sci, Milan, Italy
来源：
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION | 2017年 / 68卷 / 03期
关键词：
Children; primary hyperlipidemia; erythrocytes; phospholipids; lipid profile; omega-3; index; CORONARY-HEART-DISEASE; RED-BLOOD-CELLS; CARDIOVASCULAR-DISEASE; ATHEROSCLEROTIC PLAQUE; MEMBRANE PHOSPHOLIPIDS; DYSLIPIDEMIC CHILDREN; ESTIMATED DESATURASE; ELEVATED LEVELS; SEX-DIFFERENCES; OMEGA-3; INDEX;
D O I：
10.1080/09637486.2016.1236076
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
This study aimed at characterizing the fatty acid (FA) composition of red blood cell (RBC) phospholipids in children and adolescents with primary hyperlipidemia, and to ascertain potential association with serum lipid profile and dietary factors. At this purpose, 54 probands aged 6-17 years were recruited. Subjects showed a low omega-3 index (eicosapentaenoic acid, EPA+docosahexaenoic acid, DHA < 4%). Compared to males, females had a trend toward lower levels of total monounsaturated fatty acids (MUFA) and MUFA/saturated fatty acids (SFAs) ratio in RBCs. An inverse relationship between MUFA concentration in RBCs and serum cholesterol or HDL-C/triglycerides ratio was found. Omega-6 polyunsaturated fatty acids (n-6 PUFA) were positively associated to serum HDL-C levels, and inversely to dietary cholesterol. Fiber intake was positively associated with MUFA/SFA ratio. In conclusion, we provide the first experimental data on phospholipid FA composition of RBCs in hyperlipidemic children, showing sex differences and an overall low omega 3-index.
引用
收藏
页码：339 / 348
页数：10
相关论文
共 67 条
  • [51] Conducting omega-3 clinical trials with cardiovascular outcomes: Proceedings of a workshop held at ISSFAL 2014
    Rice, Harry B.
    Bernasconi, Aldo
    Maki, Kevin C.
    Harris, William S.
    von Schacky, Clemens
    Calder, Philip C.
    [J]. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2016, 107 : 30 - 42
  • [52] Ristic-Medic D, 2009, GEN PHYSIOL BIOPHYS, V28, P190
  • [53] FATTY-ACID COMPOSITION OF SERUM-CHOLESTEROL ESTERS, AND ERYTHROCYTE AND PLATELET MEMBRANES AS INDICATORS OF LONG-TERM ADHERENCE TO FAT-MODIFIED DIETS
    SARKKINEN, ES
    AGREN, JJ
    AHOLA, I
    OVASKAINEN, ML
    UUSITUPA, MIJ
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1994, 59 (02) : 364 - 370
  • [54] Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids
    Schaeffer, Linda
    Gohlke, Henning
    Mueller, Martina
    Heid, Iris M.
    Palmer, Lyle J.
    Kompauer, Iris
    Demmelmair, Hans
    Illig, Thomas
    Koletzko, Berthold
    Heinrich, Joachim
    [J]. HUMAN MOLECULAR GENETICS, 2006, 15 (11) : 1745 - 1756
  • [55] Procyanidins from Vitis vinifera seeds:: In vivo effects on oxidative stress
    Simonetti, P
    Ciappellano, S
    Gardana, C
    Bramati, L
    Pietta, P
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2002, 50 (21) : 6217 - 6221
  • [56] Importance of sex and gender in atherosclerosis and cardiovascular disease
    Spence, J. David
    Pilote, Louise
    [J]. ATHEROSCLEROSIS, 2015, 241 (01) : 208 - 210
  • [57] ERYTHROCYTE-MEMBRANE FATTY-ACID COMPOSITION IN HYPERCHOLESTEROLEMIA
    TAYLOR, AJ
    [J]. ANNALS OF CLINICAL BIOCHEMISTRY, 1994, 31 : 351 - 354
  • [58] Delta-5 and Delta-6 Desaturases: Crucial Enzymes in Polyunsaturated Fatty Acid-Related Pathways with Pleiotropic Influences in Health and Disease
    Tosi, Federica
    Sartori, Filippo
    Guarini, Patrizia
    Olivieri, Oliviero
    Martinelli, Nicola
    [J]. OXIDATIVE STRESS AND INFLAMMATION IN NON-COMMUNICABLE DISEASES - MOLECULAR MECHANISMS AND PERSPECTIVES IN THERAPEUTICS, 2014, 824 : 61 - 81
  • [59] Essential fatty acid status in paediatric Crohn's disease: relationship with disease activity and nutritional status
    Trebble, TM
    Wootton, SA
    May, A
    Erlewyn-Lajeunesse, MDS
    Chakraborty, A
    Mullee, MA
    Stroud, MA
    Beattie, RM
    [J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2003, 18 (04) : 433 - 442
  • [60] The role of red blood cells in the progression and instability of atherosclerotic plaque
    Tziakas, Dimitrios N.
    Chalikias, Georgios K.
    Stakos, Dimitrios
    Boudoulas, Harisios
    [J]. INTERNATIONAL JOURNAL OF CARDIOLOGY, 2010, 142 (01) : 2 - 7
1234567