Recent updates of carbapenem antibiotics

被引：147

作者：

El-Gamal, Mohammed I. ^{[1
,2
,3
]}

Brahim, Imen ^{[1
]}

Hisham, Noorhan ^{[1
]}

Aladdin, Rand ^{[1
]}

Mohammed, Haneen ^{[1
]}

Bahaaeldin, Amany ^{[1
]}

机构：

[1] Univ Sharjah, Coll Pharm, Sharjah 27272, U Arab Emirates

[2] Univ Sharjah, Sharjah Inst Med Res, Sharjah 27272, U Arab Emirates

[3] Univ Mansoura, Dept Med Chem, Fac Pharm, Mansoura 35516, Egypt

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2017年 / 131卷

关键词：

Antibiotic resistance; Carbapenems; beta-lactams; beta-lactamases; IN-VITRO ACTIVITY; RESISTANT STAPHYLOCOCCUS-AUREUS; VIVO ANTIBACTERIAL ACTIVITIES; BETA-LACTAMASE-INHIBITORS; METHICILLIN-RESISTANT; ORAL CARBAPENEM; PSEUDOMONAS-AERUGINOSA; TOMOPENEM RO4908463/CS-023; INTRAABDOMINAL INFECTIONS; ACINETOBACTER-BAUMANNII;

D O I：

10.1016/j.ejmech.2017.03.022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Carbapenems are among the most commonly used and the most efficient antibiotics since they are relatively resistant to hydrolysis by most beta-lactamases, they target penicillin-binding proteins, and generally have broad-spectrum antibacterial effect. In this review, we described the initial discovery and development of carbapenems, chemical characteristics, in vitrolin vivo activities, resistance studies, and clinical investigations for traditional carbapenem antibiotics in the market; imipenem-cilastatin, meropenem, ertapenem, doripenem, biapenem, panipenem/betamipron in addition to newer carbapenems such as razupenem, tebipenem, tomopenem, and sanfetrinem. We focused on the literature published from 2010 to 2016. (C) 2017 Elsevier Masson SAS. All rights reserved.

引用

页码：185 / 195

页数：11

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