Fumigaclavine I, a new alkaloid isolated from endophyte Aspergillus terreus

被引：9

作者：

Shen Li ^{[1
,3
]}

Zhu Li ^{[1
]}

Luo Qian ^{[1
]}

Li Xiao-Wen ^{[1
]}

Xi Ju-Qun ^{[1
,2
]}

Kong Gui-Mei ^{[2
]}

Song Yong-Chun ^{[4
]}

机构：

[1] Yangzhou Univ, Coll Med, Yangzhou 225001, Jiangsu, Peoples R China

[2] Jiangsu Key Lab Integrated Tradit Chinese & Weste, Yangzhou 225001, Jiangsu, Peoples R China

[3] Jiangsu Coinnovat Ctr Prevent & Control Importan, Yangzhou 225009, Jiangsu, Peoples R China

[4] Nanjing Univ, Inst Funct Biomol, Nanjing 210046, Jiangsu, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2015年 / 13卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Endophyte; Aspergillus terreus; Chemical constituent; Ergot alkaloid; FUMIGATUS; FUNGUS;

D O I：

10.1016/S1875-5364(15)30101-1

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The present study was designed to isolate and purify chemical constituents from solid culture of endophyte Aspergillus terreus LQ, using silica gel column chromatography, gel filtration with Sephadex LH-20, and HPLC. Fumigaclavine I (1), a new alkaloid, was obtained, along with seven known compounds, including fumigaclavine C (2), rhiioctonic acid (3), monomethylsulochrin (4), chaetominine (5), spirotryprostatin A (6), asperfumoid (7), and lumichrome (8). The structure of compound 1 was elucidated by various spectroscopic analyses (UV, MS, 1D and 2D NMR). The in vitro cytotoxicity of compound 1 was determined by MIT assay in human hepatocarcinoma cell line SMMC-7721, showing weaker cytotoxicity, compared with cisplatin, a clinically used cancer chemotherapeutic agent.

引用

页码：937 / 941

页数：5

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