Leukocyte-specific protein 1 (LSP1) - A regulator of leukocyte emigration in inflammation

被引：46

作者：

Jongstra-Bilen, Jenny

Jongstra, Jan

机构：

[1] Univ Toronto, Div Cell & Mol Biol, Toronto Gen Res Inst, Hlth Network, Toronto, ON, Canada

[2] Univ Toronto, Dept Immunol, Toronto, ON, Canada

来源：

IMMUNOLOGIC RESEARCH | 2006年 / 35卷 / 1-2期

基金：

加拿大自然科学与工程研究理事会;

关键词：

LSP1; neutrophils; leukocytes; cytoskeleton; F-actin; MAPKAPKinase2; transmigration; inflammation; Mac-1;

D O I：

10.1385/IR:35:1:65

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

LSP1 is an F-actin bundling cytoskeletal protein expressed in hematopoietic lineage and endothelial cells. We investigated the function of this protein by generating and analyzing an LSP1-deficent mouse strain and in this review we describe our findings together with those of other investigators. The results show a complex function of LSP1 in regulating leukocyte recruitment to inflamed sites. Based on current evidence, we propose that the levels of LSP1 on the cytoskeleton and the type of integrin involved are some of the critical elements which affect LSP1 function in modulating the threshold for transmigration.

引用

页码：65 / 73

页数：9

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[1] Inhibition of anti-IgM-induced translocation of protein kinase C βI inhibits ERK2 activation and increases apoptosis [J].