Rhodium(III)-Catalyzed Addition of Indoles with Boc-Imines via C-H Bond Activation

被引：4

作者：

Wang, Jinfang ^{[1
]}

Wang, Hui ^{[2
]}

Yue, Chuanjun ^{[1
]}

机构：

[1] Changzhou Inst Technol, 666 Liao He Rd, Changzhou 213032, Jiangsu, Peoples R China

[2] Changzhou Le Sun Pharmaceut Ltd, 518 Yun He Rd, Changzhou 213125, Jiangsu, Peoples R China

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2018年 / 29卷 / 06期

关键词：

rhodium(III)-catalysis; C-H activation; indole; BETA-AMINO ACIDS; ENANTIOSELECTIVE SYNTHESIS; ALKALOIDS; ALKYNES;

D O I：

10.21577/0103-5053.20170212

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A rhodium-catalyzed alkylation reaction of indoles with N-Boc-imines has been developed via C-H activation to afford a series of substituted 2-indolyl-methanamine derivatives with good functional group tolerance and regioselectivity. A wide range of indole-based alkylation products could be obtained in up to 95% yield.

引用

页码：1175 / 1182

页数：8

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