Conjugated indole-imidazole derivatives displaying cytotoxicity against multidrug resistant cancer cell lines

被引：36

作者：

James, David A. ^{[1
]}

Koya, Keizo ^{[1
]}

Li, Hao ^{[1
]}

Chen, Shoujun ^{[1
]}

Xia, Zhiqiang ^{[1
]}

Ying, Weiwen ^{[1
]}

Wu, Yaming ^{[1
]}

Sun, Lijun ^{[1
]}

机构：

[1] Synta Pharmaceut, Lexington, MA 02421 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 19期

关键词：

indole; imidazole; multidrug resistant cancer;

D O I：

10.1016/j.bmcl.2006.07.020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report herein the SAR studies of a series of indole-imidazole compounds. that demonstrate substantial in vitro anti-proliferative activities against cancer cell lines, including multidrug resistance (MDR) phenotypes. The in vitro cytotoxic effects have been demonstrated across a wide array of tumor types, including hematologic and solid tumor cell lines of various origins (e.g., leukemia, breast, colon, and uterine). (c) 2006 Elsevier Ltd. All rights reserved.

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页码：5164 / 5168

页数：5

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