Controllable stereoselective synthesis of trisubstituted alkenes by a catalytic three-component reaction of terminal alkynes, benzylic alcohols, and simple arenes

被引：43
作者：
Li, Hai-Hua [1 ]
Jin, Yin-Huan [1 ]
Wang, Jie-Qi [1 ]
Tian, Shi-Kai [1 ]
机构：
[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 16期
基金：
中国国家自然科学基金;
关键词：
TETRASUBSTITUTED ALKENES; MULTICOMPONENT REACTIONS; 4-COMPONENT SYNTHESIS; ALKENYLATION; COUPLINGS; EFFICIENT; REAGENTS; HALIDES; AMINES; CARBOALUMINATIONS;
D O I：
10.1039/b911954j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The acid-catalyzed three-component reaction of terminal alkynes, benzylic alcohols, and simple arenes provides convenient and atom-economic access to an array of both Z- and E-isomers of trisubstituted alkenes with excellent stereoselectivity by switching reaction temperature and acidic catalysts.
引用
收藏
页码：3219 / 3221
页数：3
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