Individualizing colonoscopy screening by sex and race

被引:58
作者
Lansdorp-Vogelaar, Iris [1 ]
van Ballegooijen, Marjolein [1 ]
Zauber, Ann G. [2 ]
Boer, Rob [1 ]
Wischut, Janneke [1 ]
Winawer, Sidney J. [3 ]
Habbema, J. Dik F. [1 ]
机构
[1] Erasmus MC, Univ Med Ctr Rotterdam, Dept Publ Hlth, NL-3000 CA Rotterdam, Netherlands
[2] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA
[3] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA
关键词
SOCIETY TASK-FORCE; COLORECTAL-CANCER; COST-EFFECTIVENESS; COLON-CANCER; INCOMPLETE COLONOSCOPY; VIRTUAL COLONOSCOPY; PHYSICAL-ACTIVITY; AMERICAN-COLLEGE; RISK; SURVEILLANCE;
D O I
10.1016/j.gie.2008.08.040
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: There is increasing discussion whether colorectal cancer (CRC) screening guidelines should be individualized by sex and race. Objectives: To determine individualized colonoscopic screening guidelines by sex and race for the average-risk population and to compare the cost-effectiveness of this approach with that of uniform guidelines for all. Design: We used the MISCAN-Colon microsimulation model to estimate life expectancy and lifetime CRC screening and treatment costs in a U.S. cohort of black and white men and women at average risk for CRC. We compared the base-case strategy of no screening and 3 competing colonoscopy strategies: (1) the currently recommended "uniform 10-yearly colonoscopy from age 50 years," (2) a shorter interval "uniform 8-yearly colonoscopy from age 51 years," and (3) "individualized screening according to sex and race." Results: The base-case strategy of no screening was the least expensive, yet least effective. The uniform 10-yearly colonoscopy strategy was dominated. The uniform 8-yearly colonoscopy and individualized strategies both increased life expectancy by 0.0433 to 0.0435 years per individual, at a cost of $15,565 to $15,837 per life-year gained. In the individualized strategy, blacks began screening 6 years earlier, with a 1-year shorter interval compared with whites. The individualized policies were essentially the same for men and women, because the higher CRC risk in men was offset by their shorter life expectancy. The results were robust for changes in model assumptions. Conclusions: The improvements in costs and effects of individualizing CRC screening on a population level were only marginal. Individualized guidelines, however, could contribute to decreasing disparities between blacks and whites. The acceptability and feasibility of individualized guidelines, therefore, should be explored. (Gastrointest Endosc 2009;70:96-108.)
引用
收藏
页码:96 / 108
页数:13
相关论文
共 77 条
[1]   The personalized medicine coalition - Goals and strategies [J].
Abrahams, E ;
Ginsburg, GS ;
Silver, M .
AMERICAN JOURNAL OF PHARMACOGENOMICS, 2005, 5 (06) :345-355
[2]   Colorectal cancer in African Americans [J].
Agrawal, S ;
Bhupinderjit, A ;
Bhutani, MS ;
Boardman, L ;
Nguyen, C ;
Romero, Y ;
Srinvasan, R ;
Figueroa-Moseley, C .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2005, 100 (03) :515-523
[3]  
*AM CANC SOC, 2005, COL CANC FACTS FIG S
[4]   Factors that predict incomplete colonoscopy: Thinner is not always better [J].
Anderson, JC ;
Gonzalez, JD ;
Messina, CR ;
Pollack, BJ .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2000, 95 (10) :2784-2787
[5]  
[Anonymous], 1996, Cost-effectiveness in health and medicine
[6]  
[Anonymous], 2007, COST EFFECTIVENESS D
[7]  
[Anonymous], CANC FACTS FIG 2007
[8]  
[Anonymous], 1998, FINAL REPORT MISCAN
[9]   Quality assessment of colonoscopic cecal intubation: An analysis of 6 years of continuous practice at a university hospital [J].
Aslinia, F ;
Uradonlo, L ;
Steele, A ;
Greenwald, BD ;
Raufman, JP .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2006, 101 (04) :721-731
[10]   Gender differences in colorectal cancer: implications for age at initiation of screening [J].
Brenner, H. ;
Hoffmeister, M. ;
Arndt, V. ;
Haug, U. .
BRITISH JOURNAL OF CANCER, 2007, 96 (05) :828-831