Reduced mania and depression in juvenile bipolar disorder associated with long-chain ω-3 polyunsaturated fatty acid supplementation

被引：81
作者：
Clayton, E. H. [1 ,2 ]
Hanstock, T. L. [3 ,4 ,5 ]
Hirneth, S. J. [3 ]
Kable, C. J. [3 ]
Garg, M. L. [2 ]
Hazell, P. L. [6 ,7 ]
机构：
[1] Wagga Wagga Agr Inst, NSW Dept Primary Ind, Wagga Wagga, NSW 2650, Australia
[2] Univ Newcastle, Nutraceut Res Grp, Callaghan, NSW 2308, Australia
[3] Hunter New England Area Hlth Serv, Bipolar Program, Newcastle, NSW, Australia
[4] Univ Newcastle, Sch Psychol, Callaghan, NSW 2308, Australia
[5] Univ New England, Sch Psychol, Armidale, NSW 2351, Australia
[6] Univ Sydney, Concord Clin Sch, Discipline Psychol Med, Sydney, NSW 2006, Australia
[7] Univ Newcastle, Sch Med Practice & Populat Hlth, Discipline Psychiat, Callaghan, NSW 2308, Australia
来源：
EUROPEAN JOURNAL OF CLINICAL NUTRITION | 2009年 / 63卷 / 08期
关键词：
omega-3; EPA; DHA; children and adolescents; psychiatry; juvenile bipolar disorder; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; FISH-OIL; OMEGA-3-FATTY-ACIDS; ADOLESCENTS; CHILDREN;
D O I：
10.1038/ejcn.2008.81
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Long-chain omega-3 polyunsaturated fatty acid (LCn-3PUFA) supplementation may improve symptoms of depression in children and bipolar disorder ( BD) in adults. No studies have examined the effectiveness of LCn-3PUFA supplementation in the treatment of mania and depression in juvenile BD (JBD) when given as an adjunct to standard pharmacological treatment. Eighteen children and adolescents with JBD received supplements containing 360 mg per day eicosapentaenoic acid (EPA) and 1560 mg per day docosahexaenoic acid (DHA) for 6 weeks in an open-label study. Intake and fasting red blood cell (RBC) LCn-3PUFA, mania, depression and global function were assessed before and after supplementation. RBC EPA and DHA were significantly higher following supplementation. Clinician ratings of mania and depression were significantly lower and global functioning significantly higher after supplementation. Parent ratings of internalizing and externalizing behaviours were also significantly lower following supplementation. A larger randomized controlled trial appears warranted in this participant population. European Journal of Clinical Nutrition (2009) 63, 1037-1040; doi: 10.1038/ejcn.2008.81; published online 21 January 2009
引用
收藏
页码：1037 / 1040
页数：4
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