Lifestyle factors and serum androgens among 636 middle aged men from seven countries in the European Prospective Investigation into Cancer and Nutrition (EPIC)

被引：26

作者：

Suzuki, Reiko ^{[1
,2
]}

Allen, Naomi E. ^{[2
]}

Appleby, Paul N. ^{[2
]}

Key, Timothy J. ^{[2
]}

Dossus, Laure ^{[3
]}

Tjonneland, Anne ^{[4
]}

Johnsen, Nina Fons ^{[4
]}

Overvad, Kim ^{[5
]}

Sacerdote, Carlotta ^{[6
,7
,8
]}

Palli, Domenico ^{[9
]}

Krogh, Vittorio ^{[10
]}

Tumino, Rosario ^{[11
]}

Rohrmann, Sabine ^{[3
]}

Linseisen, Jakob ^{[3
]}

Boeing, Heiner ^{[12
,13
]}

Trichopoulou, Antonia ^{[14
]}

Makrygiannis, Georgios ^{[14
]}

Misirli, Gesthimani ^{[14
]}

Bueno-de-Mesquita, H. Bas ^{[15
]}

May, Anne M. ^{[15
]}

Tormo Diaz, Maria Jose ^{[16
,17
]}

Sanchez, Maria-Jose ^{[17
,18
]}

Barricarte Gurrea, Aurelio ^{[17
,19
]}

Rodriguez Suarez, Laudina ^{[20
]}

Buckland, Genevieve ^{[21
]}

Larranaga, Nerea ^{[22
]}

Bingham, Sheila ^{[23
]}

Khaw, Kay-Tee ^{[24
]}

Rinaldi, Sabina ^{[25
]}

Slimani, Nadia ^{[25
]}

Jenab, Mazda ^{[25
]}

Riboli, Elio ^{[26
]}

Kaaks, Rudolf ^{[3
]}

机构：

[1] Natl Canc Ctr, Div Epidemiol & Prevent, Res Ctr Canc Prevent & Screening, Chuo Ku, Tokyo 1040045, Japan

[2] Univ Oxford, Nuffield Dept Med, Canc Epidemiol Unit, Oxford, England

[3] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[4] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[5] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[6] CPO Piemonte, Turin, Italy

[7] ISI Fdn, Turin, Italy

[8] Univ Turin, Canc Epidemiol Unit, Turin, Italy

[9] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[10] Fdn IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Milan, Italy

[11] Azienda Osped Civile MP Arezzo, Canc Registry, Ragusa, Italy

[12] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[13] Charite, Dept Urol, D-13353 Berlin, Germany

[14] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece

[15] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[16] Murcia Hlth Council, Dept Epidemiol, Murcia, Spain

[17] CIBERESP, Barcelona, Spain

[18] Andalusian Sch Publ Hlth, Granada, Spain

[19] Publ Hlth Inst Navarra, Pamplona, Spain

[20] Publ Hlth Directorate, Asturias, Spain

[21] Catalan Inst Oncol ICO, Res Programme, Unit Nutr Environm & Canc Canc Epidemiol, Barcelona, Spain

[22] Basque Hlth Dept Gipuzkoa, Epidemiol Unit, San Sebastian, Spain

[23] MRC Ctr Nutr Epidemiol Canc Prevent & Survival, Dept Publ Hlth & Primary Care, Cambridge, England

[24] Univ Cambridge, Dept Gerontol, Cambridge, England

[25] IARC WHO, Lyon, France

[26] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England

来源：

CANCER CAUSES & CONTROL | 2009年 / 20卷 / 06期

关键词：

Androstenedione; Androstanediol glucuronide; Testosterone; Sex hormone-binding globulin; Lifestyle factors; Diet; SEX-STEROID-HORMONES; OLDER AFRICAN-AMERICAN; BODY-MASS INDEX; FREE TESTOSTERONE; CIGARETTE-SMOKING; BINDING GLOBULIN; PROSTATE-CANCER; POSTMENOPAUSAL WOMEN; ALCOHOL-CONSUMPTION; PHYSICAL-ACTIVITY;

D O I：

10.1007/s10552-009-9326-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To evaluate the association between lifestyle and dietary factors and serum concentrations of androgens in middle-aged healthy men. We conducted a cross-sectional analysis of the association of lifestyle factors with circulating concentrations of androstenedione (A-dione), 3-alpha-androstanediol glucuronide (A-diol-g), testosterone (T), SHBG (sex hormone-binding globulin), and free testosterone (FT) among 636 men in the European Prospective Investigation into Cancer and Nutrition. Compared with the youngest age group (40-49 years), the oldest (70-79 years) had a higher mean concentration of SHBG (by 44%) and lower mean concentrations of A-diol-g (by 29%) FT (19%). Men in the highest BMI group (a parts per thousand yen29.83 kg/m(2)) had a higher mean A-diol-g concentration (by 38%) and lower mean concentration of T (by 20%) SHBG (29%) compared with the lowest (< 24.16 kg/m(2)). Current smokers had higher mean concentrations of T (by 13%), SHBG (14%), and A-dione (15%) compared with never smokers. Physical activity and dietary factors were not associated with androgen concentrations, although men in the highest fifth of alcohol intake had higher mean concentrations of A-dione (by 9%), FT (11%) compared with the lowest. Our results suggest that age, body weight, smoking, and alcohol intake are associated with circulating androgen concentrations in men.

引用

页码：811 / 821

页数：11

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