A novel and validated prognostic nomogram based on liver fibrosis and tumor burden for patients with hepatocellular carcinoma after curative resection

被引:22
作者
Huang, Jin-Long [1 ,2 ]
Fu, Yi-Peng [1 ,2 ]
Jing, Chu-Yu [1 ,2 ]
Yi, Yong [1 ,2 ]
Sun, Jian [1 ,2 ]
Gan, Wei [1 ,2 ]
Lu, Zhu-Feng [1 ,2 ]
Zhou, Jian [1 ,2 ]
Fan, Jia [1 ,2 ]
Qiu, Shuang-Jian [1 ,2 ,3 ]
机构
[1] Fudan Univ, Liver Canc Inst, Zhongshan Hosp, Key Lab Carcinogenesis & Canc Invas,Chinese Minis, Shanghai, Peoples R China
[2] Fudan Univ, Shanghai Med Sch, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Shanghai, Peoples R China
[3] Fudan Univ, Biomed Res Ctr, Zhongshan Hosp, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
hepatocellular carcinoma; laminin; liver fibrosis; nomogram; prognostic factors; STAGING SYSTEMS; SURVIVAL; RECURRENCE; CANCER; CIRRHOSIS; CELLS; CHEMORESISTANCE; PROGRESSION; HYALURONAN; MARKERS;
D O I
10.1002/jso.24895
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background and ObjectivesMost conventional staging systems were formulated concerning the tumor burden rather than the severity of liver fibrosis, which plays a central role in tumor promotion. The aim of this study was to formulate a prognostic nomogram comprehensively considering these two aspects for HCC after hepatectomy. MethodsThe prognostic significances of the four indicators namely laminin, hyaluronic acid, human procollagen type-III, and collagen type-IV that reflect liver fibrosis were explored in two independent cohorts. A nomogram was established based on the results of multivariate analysis. The predictive accuracy of the nomogram was measured by concordance index (C-index) and calibration. The decision curve analysis (DCA) was used to evaluate the clinical benefit of the nomogram. ResultsPreoperative serum laminin level is an independent prognostic factor for overall survival in HCC patients after resection. The C-indices of the nomogram in the training and validation cohorts were 0.779 and 0.719, respectively. The calibration showed optimal agreement between the prediction by nomogram and actual observation. Moreover, the C-indices and DCA revealed that the nomogram provided better clinical benefit compared with the BCLC stage, CLIP score, and AJCC 7th edition. ConclusionsThe prognostic nomogram constructed on laminin represents a superior predictive model.
引用
收藏
页码:625 / 633
页数:9
相关论文
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