Growth factors as treatment options for intestinal inflammation

被引：18
作者：
Dieckgraefe, Brian K.
Korzenik, Joshua R.
Anant, Shrikant
机构：
[1] Washington Univ, Sch Med, Siteman Canc Ctr, Div Gastroenterol, St Louis, MO 63110 USA
[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Gastrointestinal Unit,Inflammatory Bowel Dis Ctr, Boston, MA USA
[3] Washington Univ, Sch Med, Siteman Canc Ctr, Dept Med Mol Biol & Pharmacol, St Louis, MO 63110 USA
来源：
INFLAMMATORY BOWEL DISEASE: GENETICS, BARRIER FUNCTION, IMMUNOLOGIC MECHANISMS, AND MICROBIAL PATHWAYS | 2006年 / 1072卷
关键词：
growth factors; Crohn's disease; inflammatory bowel disease; sargramostim;
D O I：
10.1196/annals.1326.007
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
On the basis of several studies that have been completed to date, some growth factors appear promising for the treatment of inflammatory bowel disease: keratinocyte-like growth factor-2 (KGF-2), epidermal growth factor (EGF) enemas used in combination with oral mesalamine, somatropin (human growth hormone), and sargramostim (recombinant human GM-CSF). The results of these studies are highlighted and suggest that new insights into the regulation of intestinal immunity may provide effective synergistic or single-agent treatment alternatives to immunosuppression for inflammatory bowel disease. These data focus on the reparative components of mucosal homeostasis.
引用
收藏
页码：300 / 306
页数：7
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